摘要
目的:合成九节龙皂苷衍生物并研究其抗肿瘤活性。方法:以九节龙皂苷Ⅰ为先导物,对其30位醛基进行结构修饰,合成一系列衍生物,通过体外细胞培养方法检测其对9种常见肿瘤细胞系的抗肿瘤活性。结果:获得了3个新的皂苷修饰物,其中化合物1和化合物3对常见的9种瘤株的IC_(50)与原皂苷相比均降低(P<0.05),化合物1和化合物3对肿瘤细胞的抑制率较原皂苷增强。结论:通过对九节龙皂苷进行结构修饰,能增加其抗肿瘤活性。
Objective：To synthesize ardipusilloside（ADS） derivatives and evaluate their anti-tumor activities.Method：A series of chemical compounds were synthesized by the modification of 30-aldehyde group in ardipusilloside,and the anti-tumor activities of the three compounds were studied.Result：Three new compounds were synthesized,and two of which could enhance the anti-tumor activity when compared with ADS.Conclusion：The study establishes a synthetic method for ardipusilloside derivatives and the anti-tumor activities are worthy of further study.
出处
《中国药师》
CAS
2013年第1期6-8,共3页
China Pharmacist
基金
国家自然科学基金项目(编号:30973623)
陕西省资源主导型产业关键技术(链)项目(编号:2011KTCL03-01)
第四军医大学优秀文职人员培养基金(编号:00003383)
关键词
九节龙皂苷
结构修饰
抗肿瘤活性
Ardipusilloside
Structure modification
Anti-tumor activity
