摘要
目的探讨2型糖尿病合并脑梗死患者血清同型半胱氨酸(Hcy)水平及相关因素。方法将本院收治的40例2型糖尿病合并脑梗死患者作为糖尿病合并脑梗死组,40例脑梗死非糖尿病患者为脑梗死组。采用荧光偏振免疫分析法检测2组患者血清中Hcy水平,采用放射免疫法检测血清中叶酸及维生素B12浓度。自动生化分析仪测定患者空腹血糖浓度、C反应蛋白水平。结果糖尿病合并脑梗死组患者血清Hcy水平明显低于脑梗死组;Hcy与年龄、平均动脉压呈显著正相关;Hcy与C反应蛋白、叶酸、维生素B12呈显著负相关。结论 2型糖尿病合并脑梗死患者存在Hcy代谢异常,叶酸、平均动脉压、维生素B12等与Hcy异常有关。
Objective To explore serum homocysteine （Hcy） level and relative factors in patients with type 2 diabetes complicated with cerebral infarction. Methods Forty patients with type 2 diabetes complicated with cerebral infarction hospitalized in our hospital were considered as diabetes complicated with cerebral infarction group, and 40 patients with non-diabetic cerebral in- farction as cerebral infraction group. The levels of serum Hcy in patients of both groups were detect- ed by fluorescence polarization immunoassay, the concentrations of folio acid and vitamin B12 in serum detected by radioimmunoassay, and the concentration of fasting plasma glucose and the level of C-reactive protein in patients determined by a automatic biochemistry analyzer. Results The lev- el of serum Hcy in patients of diabetes complicated with cerebral infarction group was significantly lower than that of cerebral infarction group. Hcy significantly had a positive correlation with the age and mean arterial pressure, while having a negative correlation with the C- reactive protein, folic acid and vitamin B2. Conclusion Metabolic abnormalities are presented in patients with type 2 dia- betes complicated with cerebral infarction. Hcyabnormality is associated with folic acid, mean arteri- al pressure and vitamin B12.
出处
《实用临床医药杂志》
CAS
2013年第1期41-43,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220223)
