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治疗长QT综合征普萘洛尔的效果优于美托洛尔 被引量:3

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摘要 遗传性长QT综合征(LQTS)是一种原发性遗传性心律失常综合征,严重者可发生致心律失常性晕厥和猝死,其标志性特征为表现在心电图上QT间期延长的心脏复极异常。因为绝大多数的致命性心律失常的触发因素是交感神经活性的突然增加,所以自20世纪70年代至今13受体阻滞剂一直是治疗LQTS最重要的措施。
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2013年第1期83-83,共1页 Chinese Journal of Cardiology
基金 国家自然基金(81170089) 教育部博士点基金(20110001110046)
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  • 5Wang S, Xu D, Wu TT, et al. 131-adrenergic regulation of rapid component of delayed rectifier K + currents in guinea-pig cardiac myocytes[ J]. Mol Med Rep, 2014, 9 (5) : 1923-1928. 被引量:1
  • 6Shirnizu W, Tanabe Y, Aiba T, et al. Differential effects of beta- blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQTI and LQT2 forms of congenital long QT syndrome [ J ]. J Am Coil Cardiol, 2002, 39(12) :1984-1991. 被引量:1
  • 7Bhuiyan ZA, A1-Shahrani S, A1-Aama J, et al. Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia [J]. Front Pediatr, 2013, 1:39. 被引量:1
  • 8Ahrens-Nicklas RC, Claney CE, Christini DJ. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling [ J ]. Cardiovasc Res, 2009, 82(3) :439-447. 被引量:1
  • 9Bankston JR, Kass RS. Molecular determinants of local anesthetic action 9f beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3 [ J ]. J Mol Cell Cardiol, 2010, 48( 1 ) :246-253. 被引量:1
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