摘要
目的探讨胃癌组织中环氧化酶2(COX-2)、表皮生长因子受体(EGFR)和P糖蛋白(PgP)的表达及其临床意义。方法应用免疫组织化学法检测360例胃癌组织中COX-2、EGFR和PgP的表达,并结合其临床病理特点进行分析。结果 COX-2、EGFR和PgP在胃癌组织中的阳性表达率分别为83.9%、36.1%和68.6%。其中,COX-2和PgP在淋巴结转移与否的组间有统计学差异;EGFR与胃癌的侵袭程度有关联,PgP与患者的性别有关联。三者的表达与年龄、肿瘤分化程度无关。结论检测COX-2、EGFR和PgP可用于对胃癌的浸润和转移进行评估。
Objective To investigate the expressions and clinical significance of cyclooxy- genase-2（COX-2）, epidermal growth factor receptor （EGFR） and P glycoprotein （PgP） in gastric cancer. Methods Protein expressions of COX-2, EGFR and PgP in gastric cancer were detected by immunohistochemical method in 360 patients. Relationship of COX-2, EGFR and PgP expressions with clinicopathological characteristics were analyzed. Results The positive expression rates of COX 2, EGFR and PgP in gastric cancer tissues were 83.90//00, 36.1~//00 and 68.6%, respectively. The expressions of COX-2 and PgP in gastric cancer tissues were correlated to lymph node metastasis （P^0. 05）, but not correlated to age and tumor differentiation. EGFR expression was associated with tumor invasion. PgP expression was associated with gender. Conclusion Detection of the expressions of COX-2, EGFR and PgP is valuable in evaluating the invasion and metastasis of gastric cancer.
出处
《江苏医药》
CAS
北大核心
2013年第1期24-26,F0002,共4页
Jiangsu Medical Journal
基金
江苏省自然科学基金(BK20082321)
江苏大学高级人才启动基金(11JDC089)
关键词
环氧化酶2
表皮生长因子受体
P糖蛋白
胃癌
Cyclooxygenase-2
Epidermal growth factor receptor
P-glycoprotein
Gastric cancer
