摘要
目的 探讨食管癌组织中环氧化酶2（COX-2）表达与微淋巴管密度（MLD）的关系及其与食管癌临床病理特征和预后的关系.方法 采用免疫组织化学方法检测100例食管鳞癌中COX-2的表达,同时以D2-40为标记物,检测食管鳞癌组织MLD.对患者进行随访,分析COX-2表达和MLD与食管癌预后的关系.结果 COX-2高表达的73例食管癌组织中MLD值为99.71±39.62,明显高于COX-2低表达（23例）和无表达（4例）者（80.22±30.36, P＜0.01）.COX-2的表达与本组食管癌患者临床病理特征无关（均P＞0.05）;MLD与肿瘤浸润深度和淋巴结转移有关（P＜0.05,P＜0.01）.本组患者中76例接受了随访,中位生存期为25.5个月（7～55个月）.多因素预后分析结果显示,COX-2表达、MLD、肿瘤组织学分级及淋巴结转移是影响本组食管癌患者预后的独立危险因素.结论 COX-2在食管癌中的表达与淋巴管生成有着密切的关系,其可通过促进食管癌淋巴管的生成,从而参与肿瘤的生长浸润和淋巴结转移.COX-2表达和MLD是食管癌患者的独立预后指标,其有可能成为食管癌治疗的新靶点.
Objective To study the expression of cyclooxygenase-2 （COX-2） in esophageal carcinoma and its correlation with microlymphatic density（MLD）, and to investigate the clinicopathological and prognostic significance of COX-2 and MLD in patients with esophageal cancer. Methods COX-2 expression and MLD were detected by immunohistochemistry in 100 cases of esophageal squamous cell carcinoma. Follow up was available in 76 patients. Multivariable Cox regression was used to analyze the association between the laboratory indices and overall survival of patients with esophageal carcinoma. Results COX-2 expression was present in 73% of patients. MLD in patients with high COX-2 expression（99.71±39.62） was significantly higher than that in those with low or no COX-2 expression （80.22±30.36）（P〈0.05）. No correlations were observed between the over expression of COX-2 and clinicopathologic parameters including tumor size and lymphatic metastasis （P〈0.05）. However, MLD was associated with lymphatic metastasis and the depth of invasion （P〈0.05,P〈0.01）. In the 76 patients with followed up, the median survival was 25.5 months. Cox regression showed that the COX-2 expression, histological grade of the tumor and MLD were risk factors of overall survival of esophageal carcinoma. Conclusions COX-2 may contribute to the lymphangiogenesis in the tumor. COX-2 may be a new target point for the treatment of esophageal carcinoma. COX-2 expression and microlymphatic vessel density are of significant prognostic value for esophageal carcinoma.
出处
《中华胃肠外科杂志》
CAS
北大核心
2010年第9期699-702,共4页
Chinese Journal of Gastrointestinal Surgery
关键词
食管肿瘤
环氧化酶2
微淋巴管密度
预后
Esophageal neplasms
Cyclooxygenase 2
Microlymphatic density
Prognosis
