摘要
该综述通过对藤黄抗肿瘤药用历史的回顾、研究现状的总结,以及笔者课题组近年来的若干发现,探讨了藤黄化学生物学研究中3个关键科学问题,包括藤黄中有哪些化学成分,藤黄中的化学成分通过什么方式作用于肿瘤细胞,生物机体通过什么途径处置藤黄中的化学成分。此外,笔者还将在该综述中对以藤黄中主要化学成分为先导化合物的抗肿瘤新药开发前景提出一些思考和建议。
Gamboge, the resin of Garcinia hanburyi has had a long history of use as the traditional dye as well as a comple- mentary and alternative medicine. The antitumor activities of gamboge have been well demonstrated by inhibiting the growth and pro- gression of cancer cells both in vitro and in vivo. In order to further clarify the mode of action of gamboge, there are three key questions needed to be answered, including what＇s in gamboge？ How do the chemical components from gamboge work on cancer cells？ How do biological systems work on the chemical components from gamboge after administration？ In this review, we summarize the explorations of the answers toward these questions according to the recent progress in both of chemistry and biology research of gamboge. In addi- tion, the implication in the future research and discovery of the caged G. xanthones as anticancer agents is also discussed.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第1期19-25,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81072609)
关键词
藤黄
藤黄酸
抗肿瘤
靶蛋白
α
β-不饱和酮
迈克尔反应
代谢
磺化
gamboge
gambogic acid
antitumor
target protein
α,β-unsaturated ketone
Michael addition reaction
metabolism
sulfonation
