摘要
目的研究盐酸氨基葡萄糖联合抗骨增生片治疗膝骨关节炎(KOA)的可行性及安全性。方法 2011年1月-2012年8月选取90例KOA患者,按关节面改变部位归入A组(髌股关节面改变)、B组(胫股关节面改变)、C组(全关节软骨改变),每组30例。均予以盐酸氨基葡萄糖、抗骨增生片治疗,12周后观察治疗前后临床疗效、综合疗效及安全性等指标及评分。结果①3组比较,A组疗效高于B、C组(P<0.05);②A组与B、C两组在平地行走20 m疼痛评分、关节压痛度评分和骨关节炎指数(WOMAC)评分方面差异有统计学意义(P<0.05);③A组和B、C两组在患者自我疗效评价、医生疗效评价方面差异有统计学意义(P<0.05);④A组在治疗12周后血液血沉、C反应蛋白(CRP)、白细胞介素(IL)-1、IL-6、肿瘤坏死因子-α(TNF-α)较治疗前差异有统计表学意义(P<0.05);B组则在CRP、IL-6、TNF-α较治疗前有差异(P<0.05);C组仅在CRP、TNF-α较前有差异(P<0.05);⑤3组不良反应发生率则无明显差异(P>0.05)。结论盐酸氨基葡萄糖联合抗骨增生片治疗髌股关节面改变的KOA疗效优于胫股关节改变,且治疗方案可行、安全、优效。
Objective To evaluate the efficacy and safety of glucosamine hydrochloride combined with anti-bone hyperplasia tablets in the treatment of different types of knee osteoarthritis（KOA）.Methods Ninety patients with KOA treated between January 2011 and August 2012 were chosen to be the study subjects.They were divided into group A（patellofemoral articular surface changes）,group B（tibiofemoral articular surface changes）,and group C（total joint cartilage changes）,with 30 patients in each group.All patients were given the same combined treatment of glucosamine hydrochloride and anti-bone hyperplasia tablets.Twelve weeks after the treatment,we observed such indicators as the clinical efficacy,comprehensive efficacy and safety.Results Efficacy in group A was higher than that in group B and C.There were significant differences in 20-meter walking pain,joint tenderness score,and Western Ontario and McMaster Universities Osteoarthritis Index score between group A and group B,C.Compared with group B and C,group A patients had a significant difference in self-evaluation and doctor-evaluation of the efficacy.After 12 weeks of treatment,compared with pre-treatment conditions,group A was significantly different in erythrocyte sedimentation rate（ESR）,C-reaction protein（CRP）,interleukin（IL）-1,IL-6,and tumor necrosis factor-α（TNF-α）,group B in CRP,IL-6,and TNF-α,and group C in CRP and TNF-α.There was no significant difference among the three groups in the incidence of adverse events.Conclusion Glucosamine hydrochloride combined with anti-bone hyperplasia tablets is more effective in the treatment of KOA with patellofemoral articular changes than in that of KOA with tibia femoral joint changes,and the treatment is feasible and safe with excellent efficiency.
出处
《华西医学》
CAS
2012年第12期1792-1795,共4页
West China Medical Journal
基金
四川省中医药管理局资助项目(2008376)
四川省卫生厅资助项目(120160)
四川省骨科医院院管课题(2011014)~~
关键词
盐酸氨基葡萄糖
抗骨增生片
骨关节炎
膝
髌股关节
胫股关节
Glucosamine hydrochloride
Anti-bone hyperplasia tablets
Osteoarthritis
knee
Patellofemoral joint
Tibiofemoral joint
