摘要
目的研究基质金属蛋白酶-9(MMP-9)和组织基质金属蛋白酶抑制剂-2(TIMP-2)在人非小细胞肺癌(NSCLC)组织中的表达及其与肺癌分期、分化程度和淋巴结转移等病理特征的相关性。方法通过免疫组织化学方法检测非小细胞肺癌组织和癌周组织中MMP-9和TIMP-2的蛋白表达,进行统计学处理。结果 MMP-9和TIMP-2在肺癌组织中的表达强于癌周肺组织,在腺癌中的表达强于鳞癌,在合并淋巴结转移的肺癌组织中表达较高。结论 MMP-9或TIMP-2表达失衡是NSCLC发生发展的关键。
Objective To study the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-2 in Non-small cell lung cancer（NSCLC）,and relation to clinical pathological features.Methods The expression of MMP-9 and TIMP-2 in NSCLC and paracancer pulmonary tissue were tested by immunohistochemical stain.Results MMP-9 and TIMP-2 express in all types of tissue,strongest in adenocarcinoma,lower in squamous carcinoma,lowest in para-cancer pulmonary tissue.There was significantly different between pulmonary tissue with and without lymph node transfer.Conclusion The imbalanced expression of MMP-9/TIMP-2 protein is the key enzyme of NSCLC invasion.
出处
《河南大学学报（医学版）》
CAS
2012年第4期265-267,共3页
Journal of Henan University:Medical Science
基金
河南省卫生科技攻关项目(2006148)
