摘要
目的 探讨基质金属蛋白酶 9(MMP 9)和表皮生长因子受体 (EGFR)在非小细胞肺癌 (NSCLC)中的表达及临床意义。方法 采用免疫组织化学 (SP)法检测MMP 9和EGFR在 6 2例NSCLC组织和 18例正常肺组织中的表达。结果 6 2例NSCLC中MMP 9和EGFR阳性表达率分别为 6 7.7%和 5 8.1% ,显著高于癌旁正常肺组织(P <0 .0 0 5 )。肺癌组织中的MMP 9和EGFR的阳性表达率与肿瘤病理分级、TNM分期和淋巴结转移有密切关系 (P<0 .0 5 ) ,但与肺癌组织学类型无明显关系 (P >0 .0 5 )。MMP 9、EGFR的表达水平与NSCLC患者的预后显著相关 (P<0 .0 5 )。结论 MMP 9、EGFR可作为判断NSCLC恶性程度及预后的指标。
Objective To study clinical significance of the expression of matrix metalloproteinase-9(MMP-9),epidermal growth factor receptor(EGFR) in patients with non-small cell lung cancer(NSCLC).Methods Immunohistochemical method (SP) was used to detect the expression of the MMP-9,EGFR in 62 NSCLC tissues and 18 normal lung tissues.Results The positive expression rates of MMP-9 and EGFR were 67.7%,58.1% respectively in the 62 NSCLC.Their expression levels were significantly higher than those in the para-cancerous normal lung tissues(P<0.005).The positive rate of MMP-9,EGFR in lung cancer were closely related to the pathological grades,TNM stages and lymph noge involvement(P<0.05),but not to the histological classification of the cancer(P>0.05).The levels of MMP-9 and EGFR expression were associated with unfavovable prognosis.Conclusion MMP-9,EGFR could be used as markers of malignant potential and prognosis factor of NSCLC.
出处
《哈尔滨医科大学学报》
CAS
2004年第5期432-434,共3页
Journal of Harbin Medical University
