摘要
目的:探讨伴随精神病性症状的情感障碍的临床诊断与治疗方法。方法:选取2011年2月～2012年2月在我院治疗的380例情感障碍患者临床资料作为研究对象,平均分成2组,对照组予以阿米替林联合阿立哌唑治疗,观察组予以帕罗西汀联合阿立哌唑治疗,比较2组治疗的临床效果以及副作用情况。结果:2组间治疗后临床效果无明显的差异性,p>0.05,无统计学意义;但是对照组的口干、恶心呕吐、出汗、失眠、静坐不安、视物模糊的副作用的发生率分别为4.0%、5.3%、8.2%、7.5%、6.8%、8.5%;而观察组的口干、恶心呕吐、出汗、失眠、静坐不安、视物模糊的副作用的发生率分别为2.6%、3.9%、5.9%、7.2%、5.18%、6.0%。2组间在失眠上无明显的差异性,p>0.05,无统计学意义。但是其他的副作用则有明显的差异性,p<0.05,有统计学意义。结论:帕罗西汀联合阿立哌唑治疗情感障碍效果显著,且安全性好。
Objective： To investigate the diagnosis and treatment of the affective disorder accompanied by psychotic symptoms. Methods： Choose 25000 cases of affective disorder patients from Feb. 2011-Feb. 2012 in our hospital. They were equally divided into two groups. The control group were taken with amitriptyline combined with aripiprazole. The observation group were taken with paroxetine combined with aripiprazole. Compare the treatment clinical efficacy and complications with the two groups.Results：The clinical efficacy of the two groups after treatment had no significant differences （P〉0.05）, they had no statistical significances. But the complications incidence rate of the control group, containing the dry mouth, nausea, vomiting, sweating, insomnia, meditation disturbed and blurred vision separately were 4.0%, 5.3%, 8.2%, 7.5% ~ 6.8% ~ 8.5%; while the observation groups separately were 2.6%, 3.9%, 5.9% 7.2%, 5.18%, 6.0%. The vomiting of the two groups had no obviously differences （P〉0.05）, they had statistical significances. But other complications of the two groups had significant differences （P〈0.05）, they had statistical significances. Conclusions： The paroxetine combined with aripiprazole was obviously effective and safe for the treatment ofaffective disorder.
出处
《中国伤残医学》
2012年第12期29-30,共2页
Chinese Journal of Trauma and Disability Medicine
关键词
精神病性症状
情感障碍
临床分析
Psychotic symptom
Affective disorder
Clinical analysis
