摘要
目的:研究丹参注射液对梗阻性肾病梗阻解除后肾间质纤维化的影响。方法:将22只新西兰兔随机分为假手术组、造模组和丹参组,假手术组予术后普通喂养,造模组在解除梗阻后给予生理盐水腹腔注射,丹参组在解除梗阻后给予丹参注射液腹腔注射,观察三组的基本情况、血清学指标及肾间质病变情况。结果:丹参组血清肌酐(Cr)、尿素氮(Bun)含量较对照组低,P<0.05;丹参组病理标本中上皮细胞病变减轻,炎症细胞浸润较对照组少,间质增生减少,间质面积较对照组减少,P<0.05。结论:丹参注射液可以改善梗阻性肾病梗阻解除后肾间质纤维化情况,促进肾功能的恢复。
Aim：To explore the affect of Salvia miltiorrhiza injection treatment on renal tubular interstitial fibrosis. Methods： New Zealand rabbits were randomly divided into fake operational group control group and Salvia miltiorrhiza group,Salvia miltiorrhiza group was given Salvia miltiorrhiza injection by intraperitoneal route after relief of obstruction lately 2 weeks,compared three groups of serological markers and renal tubular interstitial fibrosis. Results： The Blood creatinine levels and Blood urea nitrogen levels in Salvia miltiorrhiza group is lower than those of the control group（P〈0.05）,the renal tubular interstitial level of Salvia miltiorrhiza group lower than control group（P〈0.05）. Conclusion：Salvia miltiorrhiza injection can improve renal tubulointerstitial fibrosis in obstructive nephropathy obstruction,promote recovery of renal function.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2012年第6期565-568,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国家中医药管理局资助项目(04-05JQ02)
关键词
丹参注射液
梗阻性肾病
肾间质纤维化
Salvia miltiorrhiza
obstructive nephropathy
renal tubular interstitial fibrosis
