摘要
目的 :观察氟哌啶醇季铵盐衍生物对冠状动脉的作用。方法 :利用氟哌啶醇所致小鼠锥体外系不良反应模型 ,观察其衍生物 (F3)的作用 ;利用猪冠状动脉条生物鉴定 ,观察F3( 10 - 6 ,10 - 5 and 10 - 4moL/L)对KCl( 10～ 4 0mmoL/L)诱导的冠脉条收缩的拮抗作用 ,阻断由KCl( 40mmoL/L)诱导的冠脉条的收缩 ;利用豚鼠离体心脏灌流 ,观察F3( 10 - 6 ,5× 10 - 6 ,10 - 5moL/L)拮抗脑垂体后叶素所致冠脉流量减少的作用。结果 :氟哌啶醇可致小鼠产生类帕金森氏综合征 ,而在F3 各剂量组中没有出现同样的作用。F3 量效依赖地拮抗由KCl所致的冠脉条收缩 ,并阻断较大剂量KCl所致的冠脉条的痉挛。F3 可以量效依赖地拮抗由脑垂体后叶素引起的离体豚鼠心脏冠脉流量减少。结论 :F3 引起冠状动脉的扩张 。
Objective: To observe the effect of quaternary ammonium salt derivation of haloperidol on coronary artery. Method: By using the model of adverse reaction of extrapyramidal system induced by haloperidol ip on mice, to observe the behavior effect of its derivation(F 3)on same dose and administration. Using the bioassay of porcine coronary artery strips, F 3(10 -6 , 10 -5 and 10 -4 moL/L)were added into the bath medium prior to KCl(10～40mmoL/L)administration to observe the effect of F 3 on dose-response curve of contraction induced by KCl, and the block action of F 3(10 -4 moL/L)on the contraction induced by KCl respectively; Using the Langendorff perfusion, to observe the effect of F 3(10 -6 , 5×10 -6 , 10 -5 moL/L)on reduction of coronary artery flow of guinea-pig induced by pituitrin. Results: Haloperidol induced Parkinsons like syndrome, but F 3 could not induce the same effect. F 3 decreased coronary artery strips contraction curve induced by KCl in dose-dependent manner. F 3 also blocked the contraction induced by KCl. F 3 antagonized the reduction of coronary flow induced by pituitrin on isolated heart of guinea-pig in dose-dependent manner. Conclusion: F 3 caused coronary artery dilation as haloperidol , and did not cause any adverse reaction of extrapyramidal system as it.
出处
《汕头大学医学院学报》
2000年第2期1-3,共3页
Journal of Shantou University Medical College
