摘要
光热治疗技术已经引起了广泛的重视,其走向应用的前提是开发出高效稳定的光热转换材料。碳基光热转换纳米材料具有毒性小、稳定性高等优点,已经成为了研究的热点。综述了碳基光热转换纳米材料(包括纳米碳管和石墨烯)的研究进展,重点论述了其表面改性技术(包括非共价键改性和共价键改性方法);随后总结了其表面功能化方法,主要有RGD、抗体、叶酸和DNA等靶向性功能化的修饰方法;最后介绍了其在光热治疗、近红外热成像等生物医药方面的应用。
Photothermal therapy technology is attracted much attention, and a prerequisite for the development of its biological applications is to obtain photothermal agents with excellent conversion efficiency and stability. Carbon- based photothermal agents is drawn increasing interest due to their advantages such as low toxicity and excellent sta- bility. The recent research progress in carbon-based nanomaterials with photothermal effects is reviewed, including carbon nanotube and graphene. The main attention is given to the advance in their surface modification technologies in- cluding non-covalent modification and covalent modification- Subsequently, the functionalization methods of carbon- based photothermal agents with RGD, antibody, folic acid and DNA are summarized. At last, their biological applica- tions, including photothermal ablation therapy and NIR photothermal imaging are introduced.
出处
《材料导报》
EI
CAS
CSCD
北大核心
2012年第23期30-33,50,共5页
Materials Reports
基金
国家自然科学基金(21107013
21171035
50902021
51272299)
高等学校博士学科点专项科研基金(20090075120014
20110075120012)
上海市青年科技启明星计划(11QA1400100)
中央高校基本科研业务费专项资金
高等学校学科创新引智计划(111-2-04)
关键词
碳基纳米材料
光热转换
制备
表面功能化
生物应用
carbon-based nanomaterials
phototherrnal conversion
preparation
surface functionalization
bio-logical application
