摘要
目的:优选三黄散瘀巴布剂的基质配方。方法:以巴布剂的外观性状和黏力为评价指标,采用单因素试验和正交试验优选三黄散瘀巴布剂的基质配方。结果:三黄散瘀巴布剂的较优基质配方为NP-700-K90-甘油(0.5∶0.4∶6)。取大黄、黄芩合提浓缩液加入卡波姆-u10NF得质量浓度0.02 g.mL-1溶液,溶胀过夜,作为A相,将聚丙烯酸钠0.5 g和聚乙烯吡咯烷酮0.4 g加入到6 g甘油中作为B相,将三氯化铝和柠檬酸加入到水中作为C相,黄柏单提浓缩液作为D相,将上述4相按A-B-C-D(10∶3∶3∶5)充分混合搅匀,搅拌15 min,涂布,盖上防黏层。结论:所优选三黄散瘀巴布剂的基质配方简单、稳定,可推广于大生产应用。
Objective： To optimize matrix formulation of Sanhuang Sanyu cataplasm. Method： Taking appearance and adhesion of cataplasm as evaluation indexes, matrix formulation of Sanhuang Sanyu cataplasm was optimized by single factor test and orthogonal test. Result： Optimized matrix formulation of Sanhuang Sanyu cataplasm was NP-700-K90-glycerol （0. 5：0. 4： 6）. 0. 02 g ~ mL-1 solution was received by adding carbomer-ul0NF into mixed extraction concentrated liquid of Rheum palmatum and Scutellaria baicalensis, swelling overnight, as A phase, 0.5 g sodium polyacrylate and 0.4 g PVP were added to 6 g glycerol as B phase, aluminum chloride and citric acid were added to water as C phase, single extraction concentrated liquid of Phellodendron phase, four phases was fully mixed with A-B-C-D （10： 3： 3： 5） , stirred 15 min, coating, chinense was as D covered with anti- sticking layer. Conclusion： Optimized matrix formulation of Sanhuang Sanyu cataplasm was simple, stable and feasible, which could be applied to industrial production.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第24期24-27,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
浙江省科技厅科技计划项目(2007C23020)
浙江省中药现代化专项资金项目(浙财企字[2008]268号)
浙江省中医药管理局项目(2006C038)
关键词
三黄散瘀巴布剂
基质配方
单因素试验
正交试验
Sanhuang Sanyu cataplasm
matrix formulation
single factor test
orthogonal test
