摘要
目的探讨中老年女性睡眠行为与子宫肌瘤(UL)的关系。方法采取以医院为基础的回顾性研究,病例为经临床诊断为UL,术后经病理证实为UL患者;对照为未患UL及其他妇科疾病的患者,病例组和对照组各385例;采用自行设计的调查表对研究对象进行调查,同时使用匹兹堡睡眠质量指数(PSQI)询问研究对象的睡眠行为;采用多因素logistic回归模型对研究对象睡眠行为与UL的比值比(OR)及其相应的95%CI进行估计。结果病例组睡眠质量、睡眠时间、睡眠效率、睡眠障碍、PSQI总得分均明显高于对照组(P<0.001);单因素分析结果显示,睡眠质量、睡眠效率、睡眠障碍及PSQI总分与UL的发生有关;为进一步控制多种潜在性混杂因素的影响,进行多因素logistic分析结果显示,评分>2分者睡眠质量(OR=2.030,95%CI=1.261～3.181,P<0.001)、睡眠效率(OR=2.437,95%CI=1.465～4.056,P<0.001)、睡眠障碍(OR=1.564,95%CI=1.002～1.862,P=0.023)发生UL危险性均高于评分<1分者;PSQI总分升高与UL呈正相关,总分5～10和>10分者发生UL的危险性均高于总分<5分者(OR=1.833,95%CI=1.308～2.497,P=0.002;OR=1.923,95%CI=1.515～2.687,P=0.019),并且随着评分的增加,发生UL的危险性也增加(P<0.05)。结论睡眠可能会对UL造成影响,因此绝经前女性应提高睡眠对UL影响的意识,保持身心愉快,定期进行妇科检查,及时发现问题,预防UL的发生。
Objective To explore the association between sleep behavior and uterine leiomyomata（UL） risk in middle aged and elderly women.Methods A hospital-based retrospective study was conducted.Cases（n=385） were pathologically confirmed with UL and controls（n=385） were women with different diseases other than gynecologic diseases.All subjects were interviewed using a structured interviewer-administrated questionnaire and sleep behavior of the subjects were inquired with Pittsburgh Sleep Quality Index（PSQI） simutaneously.The odds ratio（OR） and the corresponding 95% confidence interval（CI） for UL and component scores of sleep behavior were estimated with multiple logistic regression model.Results The case group was significantly higher in grades of subjective sleep quality,habitual sleep efficiency,sleep disturbances,and overall PSQI scores than matched controls（P0.05）.Sleep quality,habitual sleep efficiency,sleep disturbances,and overall PSQI scores were associated with UL in univariate analysis.After adjustment for multiple potential confounders,compared with the controls,for the cases with scores ≥2,sleep quality（OR=2.030,95%CI：1.261-3.181;P0.001）,habitual sleep efficiency（OR=2.437,95%CI：1.465-4.056;P0.001）,sleep disturbances（OR=1.564,95%CI：1.002-1.862;P=0.023）,and overall PSQI scores were significantly related with the risk of UL.Compared with the women with the score 5,the women with the scores of 5-10 and 10 had approximately two times risk of UL（OR=1.833,95%CI：1.308-2.497;P=0.002;OR=1.923,95%CI：1.515-2.687;P=0.014）.UL risk may increase with the increment of component score（P 0.05）.Conclusion Sleeping may be a risk factor of UL and premenopausal women should raise the consciousness of the sleep influence on UL and do regularly gynecological examinations to prevent the disease.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2012年第12期1580-1583,共4页
Chinese Journal of Public Health
基金
辽宁医学院"奥鸿大学生创新课题基金"(2011YD45)
