摘要
目的研究多肽生长因子 TGF-α与 IGF- 在长期血透 (HD)患者血清及体液中的表达特征。方法采用放射免疫分析法 ,检测 45例维持性 HD患者血清及 12 h尿液中 TGF- α与 IGF- 的水平。结果 TGF- α水平明显低于正常组 ,IGF- 则明显高于正常组。 HD后血清中两项指标水平均明显高于 HD前 ,测定 12 h尿液 TGF- α和 IGF- 含量均较正常组明显增高 (P<0 .0 5 ;P<0 .0 1)。结论尿毒症状态或血透过程透析膜等因素可激活单核细胞 ,使产生 TGF- α和 IGF- 增多。
ObjectiveTo study the expression characteristic of TGF α and IGF Ⅱ in perenninal homedialysis patient. Methods TGF α and IGF Ⅱ levels in sera and 12 h urine of 45 maintenance homedialysis patients were detected by radio immunity analysis.ResultsCompared with normal control, serum TGF α decreased significantly ( P <0 01), and IGF Ⅱ increased significantly. Both of TGF α and IGF Ⅱ levels in sera and 12 h urine increased significantly after homedialysis ( P <0 05; P <0 01). Conclusion The status of urinaemia and dialyser can stimulate mononuclear cell to sythesis more TGF α and IGF Ⅱ. [
出处
《免疫学杂志》
CAS
CSCD
北大核心
2000年第2期134-135,共2页
Immunological Journal
关键词
血液透析
放射免疫分析
TGFΑ
TGF-Ⅱ
transforming growth factor α,insulin like growth factor, homedialysis, radio immunity analysis, dialyser