摘要
不同日龄３批雄性大鼠饲氟浓度５３．２×１０^(－６)，实验３个月。结果表明，与同日龄正常对照组相比，肝、肾铝显著升高的断乳２周大鼠的血清钙、ＲＢＣ、Ｈｂ含量、红细胞平均血红蛋白量、全血锌、全血铁，骨钙、骨磷含量均出现显著变化。２８０日龄组的体重和全血磷受影响较为显著。１５０日龄的各项实验指标变化最小。从断乳２周饲氟浓度 ５３．２×１０^(－６)直至 ２４０和 ３７０日龄大鼠全血和骨骼的元素含量，仅见３７０日龄的骨骼元素含量均显著下降。骨氟含量断乳两周的是１５０、２８０日龄的１３１％，１２２％，是同日龄对照的４３９％，１５０、２８０日龄的为１５０％，１５７％，饲氟至２４０和３７０日龄的是２００％，２１５％。表明相同饲氟浓度和饲氟时间，由于高氟促成了铝的吸收，使受危害最严重的是生长发育旺盛的断乳２周的幼年大鼠。此与铝氟病的人群分布一致。骨氟沉积也以骨代谢最活跃的幼年大鼠最高。１５０日龄的青年及以后大鼠的骨氟沉积已基本实现平衡。
batches of male rats of different ages were fed with sodium fluoride (NaF) at a dose of 53.2 ×10^(-6) for 3 months. The result Showed that, compared with control group of the same age, big changes were found in the treated rats. In fats who were as old as 2 weeks after weaning (WW), marked changes of RBC and average Hb content in RBC and content of serum calcium, bind zinc, iron, bone calcium and phosphorus occurred. In 280 day-aged treated group, the effects of NaF was relatively significant while the changes of all the tested indices in 150-day-aged treated group were the smallest. The comparison of element content in blood and ho between WW group red with NaF for 240 d and the 370-day -aged group was made. The results showed that, of the latter, bone element content decreased significantly, and the WW group rats who fed on NaF for 3 months had the highest bone F content and deposition rate. For 240-and 370-day-aged treated groups, with significantly different length of treating time, the bone F content of 2 batches of rats were similar. It is shown that, under the same dose of Natl and same length of treating time, the rats who interfered the most were the WW rats who in the were in luxuriantly developing stage, which is coincident with the distribution of Al-F co-toxicosis symptoms in patient population. The highest deposition rate was found in WW rats who have active fore metabolism. In groups of 150-day-aged and elder rats, no marked increase of bone F deposition was seen.
出处
《广东微量元素科学》
CAS
2000年第1期10-14,共5页
Trace Elements Science
