摘要
药物控释高分子材料要求有良好的生物相容性。我们对聚 - (3-羟丙基 ) - DL-天冬酶胺 (PHPA)材料进行了皮下埋植实验、组织病理学观察、血生化和微核等检测。早期 ,在埋植部位出现了异物反应 ,第 13天部分小鼠肝组织小血管边出现轻度炎症反应 ,34 d后上述反应逐渐减轻或消失 ,肝肾组织细胞形态和功能基本正常。实验表明 。
To evaluate the biocompatibility of poly (3 hydroxypropyl) DL aspartamide(PHPA), we utilized the laboratory methods, including subcutaneous implantation, histological examination, blood biochemical and micronucleus test. Histological examination revealed a nonspecific foreign body reaction around the PHPA and a slight inflammation around the small blood vessels of the liver on the 13th day, but all these reactions diminished or disappeared gradually after 34 days of implantation. The structures and functions of liver and kidney were normal. The results indicate that PHPA possesses a good nature in biocompatibility.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2000年第1期19-20,28,共3页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目!(39570219)
关键词
PHPA
生物相容性
皮下埋植
聚天冬酰胺
Poly (3 hydropropyl) DL aspartamide PHPA Biocompatibility Implantation
