摘要
本文利用可生物降解的聚－α，β－ＤＬ－（２－羟乙基）天冬酰胺（ＰＨＥＡ）作为高分子载体和乙酰水杨酰氯在吡啶催化下缩合，成为聚天冬酰胺－乙酰水杨酸共价复合体，经用ＮａＯＨ溶液回流全水解后，由高效液相法测得乙酰水杨酸的接入率为３０％（ｗ／ｗ）．文中还对乙酰水杨酰氯的制备方法作了改进，收率为７５．６％。
Poly-DL-aspartic amide-acetylsalicylic acid covalent complex was synthesized by applying biodegradable poly-α,β-DL-(2-hydroxylethyl)aspartic amide as a carrier to react with acetylsalicylyl chloride in the presence of pyridine. The loaded degree of acetylsalicylic acid was determined to be 30% by means of HPLC after hydrolysizing the complex thoroughly.An improved method of preparation of acetylsalicylyl chloride was also described in this paper.
出处
《中国药物化学杂志》
CAS
CSCD
1994年第4期279-281,共3页
Chinese Journal of Medicinal Chemistry
关键词
聚天冬酰胺
乙酰水杨酸
共价复合体
天冬氨酸
DL-aspartic acid
Poly-aspartic amide
Acetylsalicylic acid
Drug sustained release
