摘要
目的系统评价益生菌对婴儿湿疹及特应性湿疹的预防作用。方法计算机检索PubMed、EMbase、MEDLINE(Ovid)、CENTRAL、CBM和CNKI数据库,收集益生菌预防婴儿湿疹及特应性湿疹的随机对照试验(RCT),检索时限均从建库至2012年2月。由2位评价员根据纳入和排除标准独立筛选文献、提取资料、评价质量和交叉核对后,采用RevMan 5.0软件进行Meta分析。结果最终纳入15个研究,共3 179例患儿。仅纳入8个质量较高的研究进行Meta分析,结果显示:益生菌组婴儿湿疹发生率低于安慰剂组,两组差异有统计学意义[RD=–0.06,95%CI(–0.10,–0.03),P<0.05];益生菌对婴儿特应性湿疹无预防作用[RD=–0.02,95%CI(–0.08,0.03),P>0.05)];益生菌对高危人群[RD=–0.09,95%CI(–0.15,–0.03),P<0.05]和普通人群[RD=–0.05,95%CI(–0.10,0.00),P<0.05]婴儿湿疹均有预防作用。结论益生菌对于婴儿湿疹有一定预防作用,但由于益生菌菌种、剂量、疗程等诸多方面的差异,其对婴儿湿疹及特应性湿疹的具体效应尚需进一步研究加以验证。
Objective To systematically evaluate the preventative effect of probiotics for infantile eczema and at- opic eczema. Methods Databases including PubMed, EMbase, MEDLINE （Ovid）, CENTRAL, CBM and CNKI were searched from inception to February 2012, so as to collect the randomized controlled trials （RCTs） on probiotics in pre- venting infantile eczema and atopic eczema. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, evaluated quality and cross-checked. Then the meta-analysis was conducted using RevMan 5.0 software. Result A total of 15 RCTs involving 3 179 infants were included. The results of meta-analyses on 8 high quality RCTs showed that： the incidence of infantile eczema was lower in the probiotics group than the placebo group, with a significant difference （RD=-0.06, 95%CI -0.10 to -0.03, P〈0.05）. Probiotics had no preventative effect on infantile atopic eczema （RD=-0.02, 95%CI -0.08 to 0.03, P〉0.05）, and had preventative effects on both high risk popu- lation （RD=-0.09, 95%CI -0.15 to -0.03, P〈0.05） and general population （RD=-0.05, 95%CI -0.10 to 0.00, P〈0.05） of infantile eczema. Conclusion Probiotics have certain preventative effects on infantile eczema. Due to the differences of probiotics in the aspects such as probiotic strain, dosage, treatment course, etc., its specific effects on infantile eczema and atopic eczema should be further tested.
出处
《中国循证医学杂志》
CSCD
2012年第11期1372-1378,共7页
Chinese Journal of Evidence-based Medicine
