摘要
目的探讨急性颅脑损伤患者白细胞介素6（IL-6）、肿瘤坏死因子α（TNF—α）、细胞间黏附分子1（ICAM-1）与神经丝蛋白H磷酸化亚型（pNF—H）及神经元特异性烯醇化酶（NSE）水平的变化和意义。方法选择急性颅脑损伤患者100例作为观察组，按损伤程度分组（轻、中、重型组），检测血清IL-6、TNF-α、ICAM-1与pNF—H、NSE水平，并与30例健康对照组比较。结果患者IL-6、TNF—α、ICAM-1与pNF—H、NSE水平均高于健康对照组（均P〈0．05）；轻、中、重型颅脑损伤患者上述指标水平差异均有统计学意义（均P〈0．05）；IL-6、TNF—α、ICAM-1与pNF-H、NSE水平均呈正相关（均P〈0．05）。结论IL-6、TNF-α、ICAM-1与pNF—H、NSE在急性颅脑损伤的病理过程中起到重要作用，其水平与病情严重程度密切相关。
Objective To explore the expression and significance of serum IL-6, TNF-α, ICAM-1, pNF-H and NSE in patients with acute brain injury. Methods 100 patients with acute brain injury were selected and divided into different groups （ mild injury, moderate injury, severe injury）. The serum levels of IL-6, TNF-α, ICAM-1, pNF-H and NSE were detected. 30 healthy persons were selected as healthy control group. Results The serum IL-6,TNF-α, ICAM-1, pNF-H and NSE levels in the patients were higher than those in the healthy control groups （all P 〈 0. 05 ）. The serum levels of them were increased steply with the order of severity（ all P 〈 0.05 ）. IL-6 ,TNF-α, ICAM-1 were positive correlated with pNF-H and NSE （ all P 〈 0.05 ）. Conclusion The serum levels of IL-6, TNF-α, ICAM-1, pNF-H and NSE were correlated with degree of injury severity. The measurement of them may contribute to predict the severity of brain injury.
出处
《中国基层医药》
CAS
2012年第23期3537-3538,共2页
Chinese Journal of Primary Medicine and Pharmacy
