摘要
肾小管上皮细胞作为肾脏固有成分之一,其形态和功能的正常对于维持肾脏正常的结构和功能起着十分重要的作用.肾小管上皮细胞在机体正常发育过程中以及各种生理病理条件下,可出现转分化现象,即细胞从表形到功能均发生改变.肾小管上皮细胞的转分化参与了多种肾脏疾病的发生、发展,本文旨在阐述肾小管上皮细胞的转分化现象及其在多种肾脏疾病中作用的研究进展.
The normal shape and functions of renal tubular epithehal cells are very important for keeping renal function. Under pathological conditions, renal tubular epithelial cells transform to myofibroblast or immunocytes. The transdifferentiation of renal tubular epithelial cells acts in the progresses of many kidney diseases, such as diabetic nephropathy and lupus nephritis. In this review, we summarize the types of transdifferentiation of renal tubular epithelial cells and its roles in kidney diseases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2012年第10期1906-1909,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81170672)
关键词
肾小管上皮细胞
转分化
类型
肾脏疾病
Renal tubular epithelial cells
Transdifferentiation
Kidney diseases
