摘要
目的探讨Protis软件在血脑屏障功能评估中的实用价值。方法用散射比浊法平行测定66例患者脑脊液与血清中免疫球蛋白(IgG、IgA、IgM)和清蛋白(albumin,ALB)的含量,并利用分析软件Protis进行数据和图形处理。结果正常8例,单纯血脑屏障受损15例,仅有鞘内合成23例,血脑屏障受损伴有鞘内合成23例。结论 Protis软件能辅助临床对中枢神经系统疾病作出初步的诊断和鉴别诊断,该软件的应用为临床提供了一种快速、可靠、直观、系统的辅助诊断方法。
Objective To explore the clinical application of the Protis system in the evaluation of blood-brain barrier function. Methods 66 patients with various neurological disorders were enrolled in this study. Immunoglobu- lin（IgG,IgA and IgM） and albumin（ALB） in serum and CSF were parallelly measured with nephelometry. The re- sults were analyzed with the Protis software system and the typical QALB and Ig patterns were determined. Results 8 cases were in normal range,15 cases had simple blood-brain barrier dysfunction,20 cases had intratheeal Ig synthesis without blood-brain barrier dysfunction and 23 cases had both blood-brain barrier dysfunction and in- trathecal Ig synthesis. Conclusion The Protis software can assist clinicians to make the preliminary diagnosis and the differential diagnosis of central nervous system disease. Therefore, it could provide a rapid, reliable, visualized and systematic assisted diagnostic method.
出处
《检验医学与临床》
CAS
2012年第20期2565-2566,2568,共3页
Laboratory Medicine and Clinic
关键词
Protis软件
脑脊液
血脑屏障
中枢神经系统疾病
Protis software system
cerebrospinal fluid
blood-brain barrier
central nervous system dis-ease
