摘要
目的探讨神经胶质瘤中血管紧张素原（angiotensinogen，AGT）mRNA的表达，以及其与临床特征的关系。方法采用实时荧光定量PCR检测36例神经胶质瘤组织和24例正常脑组织AGTmRNA的表达水平，统计分析其与临床特征的相关性。结果AGTmRNA在神经胶质瘤组织中的表达明显低于正常脑组织，差异具有统计学意义（P=0．009）。AGTmRNA在神经胶质瘤Ⅲ～Ⅳ级中的表达明显低于其在Ⅰ～Ⅱ级中的表达，差异具有统计学意义（P=O．04）；不同性别和年龄之间AGTmRNA的表达无明显差异（均P〉O．05）。结论AGTmRNA在神经胶质瘤组织中呈低表达，提示其参与神经胶质瘤的发生发展。
Objective To explore the expression of angiotensinogen(AGT) mRNA in patients with glioma and its correlation with clinical characteristics.Methods The tumor samples of 36 glioma patients and 24 normal brain samples were collected.The expression of AGT mRNA was detected by real-time fluorescent quantitative PCR and the relationship between the AGT mRNA level and clinical characteristics was analyzed statistically.Results The expression of AGT mRNA in glioma tissues was significantly lower than that in normal brain tissues(P = 0.009).Moreover,the expression of AGT mRNA in patients with pathological grade Ⅲ-Ⅳ was significantly lower than that in patients with pathological grade Ⅰ-Ⅱ(P = 0.04).However,there was no significant difference in AGT mRNA level between different ages and genders(both P > 0.05).Conclusions The expression of AGT mRNA significantly decreases in glioma tissues,which suggests that AGT may involve in the development and progression of glioma.
出处
《中国微侵袭神经外科杂志》
CAS
2012年第10期467-468,共2页
Chinese Journal of Minimally Invasive Neurosurgery
