摘要
目的探讨血管紧张素原(AGT)基因M235T多态性与中国人群结直肠癌易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法检测结直肠癌组151例患者和健康对照组202例AGT基因M235T多态性。结果结直肠癌组与对照组AGT M235T基因型和等位基因分布差异无统计学意义(P>0.05)。根据临床病理特征进行分层分析,发现携带TT基因型个体患低分化结直肠癌的风险比携带MT/MM基因型高2.50倍(P=0.008,OR=2.50;95%CI,1.26-4.97);未发现AGT M235T多态性与结直肠癌临床分期和转移状态之间存在明显相关性(P>0.05)。结论 AGT M235T多态性与中国人群结直肠癌的分化程度等临床病理特征密切相关。
Objective To investigate the association between AGT M235T polymorphism and the risk of colorectal cancer（CRC）.Methods The genotype of the AGT M235T polymorphism was genotyped in 151 patients with CRC and 202 healthy controls using polymerase chain reaction-restriction fragment length polymorphism assay.Results Patients carrying the TT genotype of the AGT M235T polymorphism had a 2.50-fold increased risk of developing poorly differentiated CRC compared with those carrying the MT/MM genotypes（P=0.008,OR=2.50;95%CI,1.26-4.97）.However,no significant association was found between patients with CRC and controls in overall analysis.Similarly,no significant association was observed between the AGT M235T polymorphism and both clinical stages and metastasis status（P0.05）.Conclusion The AGT M235T polymorphism related to clinical characteristics of differentiation grade.
出处
《中国实验诊断学》
2012年第11期2025-2027,共3页
Chinese Journal of Laboratory Diagnosis
