摘要
目的探讨大豆肽钙对大鼠钙表观吸收率及骨密度的影响。方法将雄性Wistar大鼠50只按体质量均衡原则随机分为5组：低钙对照组、碳酸钙对照组及大豆肽钙低、中、高剂量组，各组大鼠自由进食相应的专配饲料。实验第4周末，进行3d的钙代谢实验，计算各组的钙表观吸收率；大鼠喂养13周后处死，剥离左、右侧股骨。取右侧股骨测定骨钙含量，左侧股骨测定骨密度。结果（1）钙代谢实验：碳酸钙对照组钙表观吸收率为69．9％，而中、高剂量大豆肽钙组分别为82．6％和77．4％，差异有统计学意义（F=31．371，P=0．000，0．001）；（2）骨密度实验：与低钙对照组比较，大豆肽钙中、高剂量组大鼠体质量（F=3．150，P=0．010，0．002）、股骨质量（F=3．195，P=0．015，0．002）、骨钙含量（F=4．506，P=0．004，0．001）、股骨中点骨密度（F=6．185，P=0．006，0．000）及远心端骨密度（F=6．081，P=0．027，0．000）均增加明显，与碳酸钙对照组比较，除体质量指标（F=3．150，P=0．212）外，大豆肽钙高剂量组也呈现相同的结果（P值分别为0．046，0．024，0．013，0．001）。结论大豆肽钙可促进钙的吸收，增加大鼠骨密度。
Objective To investigate the effects of soybean peptide calcium on apparent calcium absorption rate and bone mineral density of rats. Methods Totally 50 male Wistar rats were divided into 5 groups at comparable body weight： the low calcium control group, calcium carbonate control group and 3 groups with low, medium and high dose of soybean peptide calcium（SPC）. Rats of each group were fed with designed forage. At the end of the fourth week of the feeding, calcium metabolic experiment was performed for 3 days and the apparent calcium absorption rate was calculated. Three months later, the left and right femurs of the rats density. Results Apparent calcium absorption were stripped to assay the bone calcium and bone rate of the calcium carbonate control group was 69. 9%, which was lower than medium（82.6%） and high doses（77.4%） of soybean peptide calcium groups（F=31. 371,P 0.000,0.001）. Compared with the low calcium control group, rats with medium and high doses of SPC had obviously increased levels of weights（F= 3. 150,P=0.010, 0.002）, bonemass（F 3.195,P=0.015,0.002）, calcium content （F=4.506,P=0.004,0.001）and bone mineral density of midpoint（F=6. 185,P=0. 006,0. 000） and far end of femur （F=6. 081,P= 0. 027,0. 000）. Despite of the weight index （P〉0.05）, the high dose of soybean peptide calcium group also had the same results as the calcium carbonate control group （P=0.046, 0.024, 0.013, 0. 001）. Conclusions Soybean peptide calcium can promote the apparent calcium absorption rate and increase the bone mineral density.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2012年第10期903-905,共3页
Chinese Journal of Geriatrics
关键词
大豆食品
钙
膳食
骨密度
Soy foods
Calcium, dietary
Bone mineral density
