摘要
目的:观察骨痹诊疗方案中中医药治疗方法的临床疗效和安全性,为进一步优化骨痹诊疗方案、制定骨痹临床路径奠定基础。方法:来源于骨痹协作分组7家单位的骨痹患者320例,采用中医辨证内治为主,配合中医外治的综合治疗方案,治疗4周。结果:中医药治疗能显著改善骨痹患者中医证候积分、Lequesne、WOMAC(VAS)、关节疼痛、肿胀、活动评分及关节功能分级,降低升高的ESR、CRP,ESR治疗前后比较,差异有显著性意义(P<0.01),其疾病疗效、证候疗效总有效率达88.44%和82.50%,且未出现明显毒副作用和不良反应。结论:本验证方案取得的临床疗效与诊疗方案提供的疗效一致,为治疗OA的一种安全有效的治疗方案,值得进一步深入研究和推广应用。
Objective： In order to further improve GuBi therapeutic regimen and lay the foundation for making GuBi clinical pathway,we observed the clinical efficacy and safety of TCM therapy in GuBi thera- peutic regimen. Methods：In the four weeks ,320 patients from seven hospitals in GuBi cooperating group were given comprehensive treatment of TCM which contains internal and external therapy. Results：TCM therapy can significantly improve patients with TCM score, Lequesne index,WOMAC score and joint pain, swelling, activity and function and can reduce the ESR, CRP and ESR elevated. Compared before and after treatment, which has significant difference（ P 〈 0.01 ）. The effective rates of disease and syndrome were respectively 88. 44% ,82.50% %. Obvious side effects and adverse reactions were not observed. Conclusion： Clinical effects of GuBi therapeutic regimen we verified accord with that of the original therapeutic regimen. Which is a safe and effective treatment in OA and worth further studying and spreading.
出处
《风湿病与关节炎》
2012年第1期16-21,共6页
Rheumatism and Arthritis
基金
国家中医药管理局"十一五"重点专科优势病种骨痹诊疗方案临床验证项目
