摘要
目的探讨PTEN和血管内皮生长因子(VEGF)在膀胱移行细胞癌中的表达及相关性。方法采用免疫组织化学SP法检测52例膀胱移行细胞癌和10例正常膀胱黏膜组织中PTEN和VEGF的表达。结果 PTEN、VEGF在膀胱移行细胞癌组的阳性表达率分别为71.2%和57.7%,与对照组相比差异均有统计学意义(P<0.05)。PTEN表达与膀胱肿瘤分级、分期呈负相关(P<0.05),而VEGF的表达与肿瘤分级、分期、复发呈正相关(P<0.05)。PTEN表达和VEGF表达呈显著负相关(rs=-0.336,P<0.05)。结论 PTEN和VEGF表达对膀胱癌的生物学行为有重要影响。
Objective To explore the expression of PTEN and VEGF and their correlation in bladder transitional cell carcinoma. Methods SP method of immunohistochemistry was used to monitor the expres- sions of PTEN and VEGF in 52 cases of bladder transitional cell carcinoma and 10 cases of normal bladder. Results The expression rates of PTEN and VEGF were 71.2% and 57.7% in bladder carcinoma group and there were statistically significant difference with those in the control group （ P 〈 0.05 ）. The expression of PTEN had negative correlation with carcinoma pathologic grade and clinical stage（ P 〈 0.05 ）. The expression of VEGF had positive correlation with pathologic grade, clinical stage and recurrence of carcinoma（ P 〈0.05 ）. And the expression of the two factors had negative correlation with each other（ rs = -0. 336,P 〈 0.05 ）. Conclusion PTEN and VEGF expression have significant effect on the biological behavior of bladder transi- tional cell carcinoma.
出处
《医学综述》
2012年第17期2876-2878,共3页
Medical Recapitulate
关键词
膀胱移行细胞癌
PTEN
血管内皮生长因子
免疫组织化学
生物学行为
Transitional-cell cm＇cinoma of bladder
Phosphatase and tensin homology deleted on chro-mosometen
Vascular endothelial growth factor
Immunohistochemistry
Biological behavior
