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抑癌基因PTEN与肿瘤的研究进展 被引量:3

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摘要 PTEN基因是目前发现的第一个具磷酸酶活性的抑癌基因,与数种具肿瘤倾向的遗传性疾病及多种散发性肿瘤有关。PTEN能特异性地使磷脂酰肌醇-3,4,5三磷酸[PIP3]去磷酸化,而拮抗PI3K/AKT信号通路发挥作用。PTEN具有调节细胞生长、增殖、迁移等多种效应。
出处 《国外医学(生理病理科学与临床分册)》 2005年第3期257-260,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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