摘要
以卡马西平、丙戊酸等为代表的传统抗癫痫药物(AEDs)由于价格低廉,效果稳定而仍广泛应于临床,但其能通过多种机制对骨髓造血功能造成全面的抑制,并可形成血小板自身抗体以及对血小板的直接毒性作用,从而导致再生障碍性贫血、出血以及急性髓样白血病样反应等一系列不良反应。而以托吡酯、奥卡西平、拉莫三嗪等为代表的新型AEDs血液系统毒性较小,罕有严重血液系统不良反应的发生,临床应用安全性高。
Traditional antiepileptic drugs （ AEDs ） represented by carbamazepine, valproic acid are still widely used in clinic due to low prices and stable effect, but it results in full inhibition of hematopoietic func- tion of hone marrow through multiple mechanisms, and can form a platelet auto-antibodies and direct toxic effects on platelets, resulting in a series of adverse reactions such as regeneration anemia, hemorrhage and a- cute myaloid leukemia-like reaction;while new AEDs represented by topiramate, lamotrigine, oxcarhazepine have less toxicity to the blood system, severe hematological adverse reaction is rare, and the clinical applica- tion safety is high.
出处
《医学综述》
2012年第17期2839-2841,共3页
Medical Recapitulate
关键词
抗癫痫药物
血液系统
损伤
Antiepileptic drugs
Blood system
Damage
