摘要
目的 :了解肿瘤医院药品不良反应(ADR)发生的特点及规律,为临床合理用药和ADR监测工作提供参考。方法:对我院2014年1月-2016年4月上报的ADR进行统计,分析ADR涉及的患者性别、年龄、药品种类、给药途径、累及器官/系统、报告人职业等信息。结果 :共报告ADR 271例,女性报告多于男性(60.9%vs.39.1%);年龄≥50且<70岁患者ADR报告最多(60.1%);静脉给药致ADR发生率最高(94.4%);抗肿瘤药物引起的ADR数居于首位(196例,72.3%);累及器官/系统主要是血液系统毒性(51.7%);严重ADR报告率较高(52.8%);报告人职业中,医师与药师上报例数相近(50.6%vs.48.3%)。结论 :临床治疗中应该加强抗肿瘤药物ADR的监测,以提高患者用药的安全性和治疗依从性。
Objective:To investigate the characteristics of adverse drug reactions(ADRs) occurred in a tumor hospital and provide a reference for rational drug use and monitoring of ADRs. Methods:The ADRs reported in Baotou Tumor Hospital from January 2014 to April 2016 were analzyed, including the genders and ages of patients as well as the durg species, route of administration, involved organs or systems and report personnel's career. Results:A total of 271 cases of ADRs were reported, which was more in female than in male(60.9% vs. 39.1%). Most of the ADRs were reported in the patients at ages not less than 50 but less than 70 years(60.1%) and induced by intravenous administration(94.4%). The case number of ADRs induced by anti-tumor drugs(196, 72.3%) ranked the first. The ADRS mainly involved with blood system(51.7%). The reproted incidence of severe ADRs was 52.8%. However, the case numbers reported by physician was similar to that by pharmacists(50.6% vs. 48.3%). Conclusion:The monitoring on ADRs induced by anti-tumor drugs should be strengthened in clinic so as to improve the compliance of patients and safety of drugs.
出处
《中国执业药师》
CAS
2017年第3期51-54,共4页
China Licensed Pharmacist
关键词
药品不良反应
分析
抗肿瘤药物
合理用药
Adverse Drug Reaction(ADR)
Analysis
Anti-tumor Drug
Rational Drug Use
