摘要
目的:探讨奥卡西平引发不良反应(ADR)的特点、发生机制、易感因素及临床转归,为临床安全用药提供参考。方法:收集2016～2017年我院进行奥卡西平血药浓度监测的404例门急诊及住院患者资料,利用Excel表对患者的一般情况、用药情况、癫痫控制情况、血药浓度监测及ADR发生情况进行统计分析。结果:经关联性评价确定为ADR的患者共56例,以中枢及外周神经系统损害(52. 78%)、皮肤及其附件损害(19. 44%)和胃肠系统损害(12. 50%)较为多见。已知ADR共41例,新的ADR共12例,罕见ADR 3例,其中严重ADR 1例。经停药、换药、调整剂量及对症支持治疗后,除2例脱发、1例嗜睡、1例体重增加的患者未完全好转,其余均好转。结论:奥卡西平所致ADR存在个体差异,10岁以内儿童较为多见,基因检测及血药浓度监测有利于个体给药方案的制定,以保障患者用药安全、有效。
Objective：o explore the characteristics,the mechanism,predisposing factors and clinical outcomes of adverse drug reactions（ ADR） induced by oxcarbazepine to provide reference for clinical safe medication. Methods：All the clinical data were collected of 436 patients monitored valproate serum concentration from January 2016 to December2017 in Xi’an Central Hospital. The general situation,medication,epilepsy control,blood drug concentration monitoring and ADR of patients were statistically analyzed by Excel. Results：There were 56 cases of ADR occurred in 404 patients by correlation evaluation. The central and peripheral nervous system damage（52. 78%）,skin and its accessories damage（19. 44%） and gastrointestinal system damage（12. 50%） were more common. There were 41 cases of common ADR,12 cases of new ADR,3 cases of rare ADR,including one sever ADR case. Except for 2 cases of alopecia,1 cases of somnolence and 1 cases of weight gain were not fully recovered,the rest of the patients were recovered completely after stopping or withdrawing drugs,adjusting the dose and symptomatic supportive treatment. Conclusion：Oxcarbazepine ADR has individual differences. The major population of oxcarbazepine ADR is children（ 〈 10 years）. Gene detection and blood drug concentration monitoring are beneficial to the formulation of individual drug program,so as to ensure the safety and effectiveness of drug use.
作者
白荷荷
聂晓静
韩小年
马莉
吕建华
王园姬
Bai Hehe;Nie Xiaojing;Hart Xiaonian;Ma Li;Lv Jianhua;Wang Yuanji(Department of Pharmacy,Xi＇an Central Hospital,Xi＇an 710003,China;Department of Pharmacy,Xi＇an No.1 Hospital)
出处
《药物流行病学杂志》
CAS
2018年第11期739-743,共5页
Chinese Journal of Pharmacoepidemiology
关键词
奥卡西平
药品不良反应
癫痫
血药浓度
Oxcarbazepine
Adverse drug reactions
Epilepsy
Serum concentration
