摘要
阿尔茨海默病是一种神经系统变性疾病,在临床和基础方面的各项研究均表明阿尔茨海默病患者存在血管病变,阿尔茨海默病不仅是神经元退行性病变,而且是以血管功能失调为特征的血管病变。血管内皮生长因子除了具有血管生成作用外,还具有神经保护及营养作用,血管内皮生长因子的缺乏,导致低灌注和神经元变性,表明它在阿尔茨海默病神经元损伤相关病理过程中具有重要作用。
Alzheimer disease （AD） is a kind of neurodegenerative disorders, clinical and basic researches of which show that there are vascular-mediated pathological changes in AD patients. AD is not only a neuro- degeneration but also a kind of vasculopathy characterized by vascular dysfunction. Vascular endothelial growth factor（VEGF） not only plays an important role in angiogenesis but also has neuroprotective and neuro- trophic effects. The lack of VEGF leads to hypoperfusion and neuron degeneration,which demonstrates its im- portant function in the neuron injury related pathologic process of AD.
出处
《医学综述》
2012年第17期2740-2743,共4页
Medical Recapitulate
基金
2007年黑龙江省政府博士后基金资助(LRB07-057)
关键词
阿尔茨海默病
脑血管损伤
血管内皮生长因子
Alzheimer disease
Brain v-ascular injury
Vascular endothelial growth factor
