摘要
目的通过观察荣络健脑饮对脑缺血再灌注大鼠神经功能缺损评分的影响及其对神经营养因子的生成作用,研究荣络健脑饮的神经保护机制。方法采用改良Longa法建立大鼠脑缺血再灌注模型,与补阳还五汤作对照,观察荣络健脑饮对大鼠神经功能缺损程度评分的影响,及大鼠脑组织神经生长因子(NGF)、脑源性神经营养因子(BDNF)、碱性成纤维生长因子(bFGF)的表达。结果荣络健脑饮能明显改善脑缺血再灌注大鼠神经缺损症状,促进大鼠脑组织NGF、BDNF、bFGF的表达,与补阳还五汤比较有显著差异。结论荣络健脑饮可通过促进大鼠脑组织神经营养因子的表达,减轻脑缺血再灌注损伤,发挥神经保护作用。
Objective： To investigate the effects of Rongluojianuao Decoction on the neurological defect score and the expression of NTF in rats with cerebral ischemia-reperfusion and to explore the neuroprotective mecha- nisms of Rongluojiannao Decoction. Methods： The model of cerebral ischemia-reperfusion was made according the modified Longa method. And then,they were observed the neurological defect score and the expression of NGF, BDNF,bFGF in the brain. Results： Rongluojiannao Decoction was much more effective than Buyanghuanwu Decoction in the aspects of alleviating the symptoms of the nuerological defect and increasing the expression of the NGF,BDNF and bFGF in the brains of the rats with cerebral ischemia-reperfusion. Conclusion： Rongluojiannao Decoction could play a role of neuroprotection through promoting the expression of NTF and mitigate the injury of ischemia-reperfusion.
出处
《中国中医急症》
2012年第9期1425-1427,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
山东省中医药科技发展计划项目(2009-061)
