摘要
目的:了解造血干细胞移植患者的长期生存质量。方法:进行造血干细胞移植、年龄在16岁以上的67例接受随访患者,随访时平均生存期为29.01(6～112)个月。通过门诊现场调查、电话随访及E-mail方式收集病历。采用SF-36、QLQ-C30及改良的性生活调查量表对患者移植后的总体健康、躯体功能、社会活动功能、日常活动、日常精神状态、身体疼痛、情绪功能、认知功能及角色功能,性生活及月经、生育等方面进行调查。结果:同正常健康人相比,造血干细胞移植后患者在身体健康、躯体功能、社会功能及心理适应能力上明显下降(均P<0.01)。造血干细胞移植对女性患者的月经及生育均有影响,95%的女性患者在移植后无正常月经,几乎所有的女性患者在移植后无正常的生育功能。移植前及移植后性生活质量均较正常人差,差异有统计学意义(P<0.05或P<0.01),移植后男性及女性患者在性生活上差异无统计学意义(P>0.05)。结论:造血干细胞移植对患者健康状态有着长而深远的影响,应采取有计划的、个体化的措施,同时予以患者必要的心理治疗及激素替代治疗,提高移植后生存质量。
Objective：To pay attention to the long-term quality of life of patients after hematopoietic stem cell transplantation（HSCT）.Method：A total of 67 adult patients who ever received HSCT and could correctly understand the language and characters were enrolled.The average survival period is 29.01 months（6 — 112 months）.The data is collected through outpatient surveys,telephone follow-up and Email.their QOL was assessed by SF-36,QLQ-C30 and improved sex life questionnaire.Aspects of the evaluation including general health,physical function,social activities,functions,daily activities,daily mental state,physical pain,emotional function,cognitive function and role function and sexual life and menstruation,fertility and other aspects of the investigation.Result：Statistical analysis found the HSCT survivor group reported poorer status relative to the HC group for all HRQOL outcome clusters including physical health,physical functioning,social functioning,psychological adjustment,and dyadic adjustment（P0.01）.Hematopoietic stem cell transplantation have a significant impact on the menstruation and fertility of woman,nearly 95% of female patients don＇t have menstrua after transplantation,and no fertility is reported.In sexual life,rank sum test shows that pre-transplant and post-transplant quality of life worse than normal.There is statistically significant（P0.05 or P0.01）.There is no significant difference between male and female patients after transpatation in the sexual life（P0.05）.Conclusion：Hematopoietic stem cell transplantation have a long and profound influence with the patients.A planned individual measures and necessary psychological treatment and hormone replacement therapy should be taken to improve the quality of life after transplantation.
出处
《临床血液学杂志》
CAS
2012年第5期562-565,共4页
Journal of Clinical Hematology
关键词
造血干细胞移植
生存质量
性生活
hematopoietic stem-cell transplantation
quality of life
sexual life
