摘要
目的:探讨红花黄色素(soor yellow,SY)对早期糖尿病肾病(diabetic nephropathy,DN)患者血清细胞因子的影响。方法:将60例早期DN患者随机分为对照组(30例)和治疗组(30例),对照组采用常规西医基础治疗,治疗组在此基础上加用SY。采用酶联免疫吸附法(ELISA)测定两组患者治疗前及治疗30d后血清白细胞介素-8(Interleukin-8,IL-8)、高敏CRP(high sensitive CRP,hs-CRP)表达水平,并检测治疗前、后空腹血糖(fasting blood glucose,FBG)和尿微量白蛋白排泄率(urinary albumin excretion rate,UAER)水平。结果:治疗30d后,对照组和治疗组患者血清FBG水平与治疗前血清FBG水平比较下降,差异有统计学意义(P<0.01),但对照组治疗30d后IL-8、hs-CRP、UAER水平无明显降低,与治疗前比较差异无统计学意义(P>0.05);治疗组使用SY治疗30d后与治疗前比较IL-8、hs-CRP、UAER水平均明显下降,差异有统计学意义(P<0.01),而且治疗组与对照组治疗后比较IL-8、hs-CRP、UAER明显下降,差异有统计学意义(P<0.01)。结论:红花黄色素可减低早期DN患者血清IL-8、hs-CRP的表达,抑制炎症反应,降低尿白蛋白,起到了对早期DN患者的肾脏保护作用。
Objective： To investigate the effect of soflor yellow （SY） on inflammatory cytokines in patients with early diabetic nephropathy（DN）. Methods：Sixty patients with early DNwere randomly assigned into the control group （n =30）treated by the con- ventional Western medicine treatment and the treated group（ n = 30）treated by SY combined with the conventional Western medicine treatment. Serum High sensitive CRP（CRP） and interleukin -8 （IL- 8 ）were determined with ELISA before and after treatment, and fasting blood glucose （FBG）and urinary albumin excretion rate（UAER） were examined as well. Results ：The FBG of the control group were lower in both groups after treatment than those before treatment （P 〈 0.01 ）. After treatment, the levels of IL - 8, bs - CRP, UAER in the control group were not noticeably reduced than those before treatment （P 〉 0.05 ） ,the levels of IL- 8 ,hs -CRP,UAER in the treated group were more noticeably reduced than those before treatment （P 〈 0.01 ）and those in the control group after treatment （P 〈 0.01 ）. Conclusion：SY could retard the development of early DN by decreasing concentration of serum IL- 8 and hs -CRP, inhibiting inflammatory reaction and regulating the production of urinary albumin.
出处
《中国中西医结合肾病杂志》
2012年第8期698-700,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
天津市自然科学基金资助项目(No.09JCYBJC09900)
