摘要
目的:通过观察益心定悸方对近似冠心病快速心律失常大鼠的心电图、Na+-K+ATPase影响的研究,探讨其防治心律失常的确切作用机制。方法:采用结扎冠状动脉的方法诱发大鼠快速心律失常为实验动物模型,观察Ⅱ导联心电图心律失常出现的时间、持续时间;采用酶促及定磷法测定Na+-K+ATPase的影响。结果:与模型对照组比较,益心定悸方组大鼠心律失常的出现时间最迟,心律失常持续时间最短,差异有统计学意义(P<0.01);与模型对照组比较,益心定悸方组大鼠室性心动过速(VT)发生率较低,与西药对照组作用相当。结论:益心定悸方对近似冠心病性心律失常大鼠有良好的拮抗作用;益心定悸方可能通过增强Na+-K+ATPase活性,起到防治冠心病快速型心律失常的作用。
Objective： To observe the herbs prescription of Yixin Dingji on rats which was similar to suffering from coro- nary heart disease with tachyarrhythmia in ECG, Na ＋ -K ＋ ATPase, the research explored the exact mechanism of drug prevention and treatment of cardiac arrhythmia. Methods： Using the rats of tachyarrhythmia induced by coronary artery ligation as the experimental animal models, and observe the occurrence time of II -lead ECG arrhythmia, the duration; and effects of the enzymatic and phosphorus fixed methods to determine the Na ＋ - K ＋ ATPase. Results ： Electrocardio- grams showed rats in the group of using the herbs prescription had the latest time of occurrence of arrhythmia, the shor- test duration of arrhythmia, ventricular taehycardia （VT） lower incidence, compared with the model control group the difference was statistically significant （P 〈 0.01 ）, a considerable role in the control group with western medicine. Con- clusion： The herb prescription on rats similar to suffering from coronary heart disease with tachyarrhythmia has a good antagonism; the herb prescription may play a preventive and therapeutic role in coronary heart disease with taehyarrhyth- mia by enhancing the activity of Na ＋ - K ＋ ATPase .
出处
《中医药学报》
CAS
2012年第3期45-46,共2页
Acta Chinese Medicine and Pharmacology
