摘要
目的观察单倍、三倍剂量阿苯达唑和甲苯咪唑治疗土源性线虫感染的效果。方法采用随机对照试验,对314位调查对象随机分为阿苯达唑(400mg)、甲苯咪唑(500mg)、三倍阿苯达唑(400mg,3d)、三倍甲苯咪唑(500mg,3d)等4组,对各药物组治疗蛔虫、钩虫、鞭虫和绦虫感染的疗效进行观察,计算治愈率和粪样虫卵下降率。结果阿苯达唑治疗钩虫的疗效优于甲苯咪唑,两药单倍剂量对钩虫的治愈率分别为69.1%和31.0%,三倍剂量组治愈率分别为92.0%和54。0%,虫卵下降率单倍剂量组为97.3%和83.6%,三倍剂量组为99.7%和96.4%。控制鞭虫感染,三倍剂量疗效优于单倍剂量。两驱虫药物单倍或三倍剂量对蛔虫感染疗效显著(治愈率在93.0%～96.8%之间,虫卵下降率均大于99.9%)。三倍剂量对绦虫感染的治愈率为100%,而单倍剂量仅为50%。结论治疗钩虫和鞭虫感染,三倍剂量方案可获得较高的治愈率。
Objective To survey the efficacy of albendazole and mebendazole against soil-transmitted helminths（STH） in oral single doses and triple doses of albendazole or mebendazole.Methods A randomized controlled trial was conducted with 314 individuals divided into a group given i） albendazole（400 mg）;ii） mebendazole（500 mg）;iii） a triple dose of albendazole（400 mg×3 d）,or iv） mebendazole（500 mg×3 d）.Efficacy against Ascaris lumbricoides,Trichuris trichiura,and Taenia spp.was observed by calculating the cure rate（CR） and fecal egg reduction rate（ERR）.Results Albendazole cured significantly more hookworm infections than mebendazole,with a CR of 69.1% versus one of 31.0% in a single dose and a CR of 92.0% versus one of 54.0% for a triple dose.Albendazole resulted in an ERR of 97.3% versus one of 83.6% in a single dose and 99.7% versus one of 96.4% in a triple dose.A triple dose was more efficacious at controlling T.trichiura infection than was a single dose.Both drugs had significant efficacy against A.lumbricoides（CR： 93.0%-96.8%;ERR：99.9%）.The CR in response to Taenia spp.was 100% for a triple dose but only 50% for a single dose.Conclusion A triple-dose regimen is warranted to cure hookworm and T.trichiura.
出处
《中国病原生物学杂志》
CSCD
北大核心
2012年第5期360-362,366,共4页
Journal of Pathogen Biology
关键词
土源性线虫
阿苯达唑
甲苯咪唑
疗效
Soil-transmitted helminths
albendazole
mebendazole
efficacy
