摘要
目的观察单次和双次阿苯达唑治疗人体土源性线虫感染的疗效。方法2015年10月—2016年1月,选择云南省西双版纳州勐海县布朗山乡5所小学2~6年级的小学生进行基线调查,连续2 d收集粪样,每人每天1份,每份粪样采用Kato-Katz法制作3张加藤片镜检,结果为阳性(蛔虫、钩虫、鞭虫单一或混合感染)的学生接受阿苯达唑治疗(一次口服400 mg)。服药后3 d连续2 d收集粪样并镜检。4周后同一批学生再次服用阿苯达唑片剂400 mg,3 d后连续2 d收集粪样并镜检。2次服药后均同时开展问卷调查,统计不良反应情况。经2次服药后仍然阳性的学生再服用阿苯达唑片剂治疗1次。将5所小学按行政村归纳,统计不同行政村鞭虫感染治疗疗效。率的比较采用卡方检验。结果5所学校共调查438人,土源性线虫感染率82.19%(360/438)。男生感染率为79.19%(175/221),女生为85.25%(185/217),差异无统计学意义(χ2=2.754,P>0.05);布朗族、拉祜族、哈尼族、其他民族学生土源性线虫感染率分别为89.79%(299/333)、90.57%(48/53)、21.43%(9/42)、4/10(χ2=133.781,P<0.05);2~6年级学生土源性线虫感染率分别为73.97%(54/73)、90.38%(94/104)、73.56%(64/87)、87.50%(28/32)、84.51%(120/142)(χ2=13.700,P<0.05)。蛔虫、钩虫、鞭虫感染率分别为52.51%(230/438)、35.39%(155/438)、73.29%(321/438),其中第1次服药后蛔虫、钩虫、鞭虫感染治愈率分别为94.24%(180/191)、63.64%(77/121)、2.64%(7/265),第2次服药后蛔虫、钩虫、鞭虫感染治愈率分别为98.77%(161/163)、91%(91/100)、6.33%(14/221)。蛔虫、钩虫、鞭虫感染者服用1、2次阿苯达唑治愈率差异均有统计学意义(χ2=5.107、22.487、3.976,P<0.05)。蛔虫、钩虫、鞭虫轻、中、重度感染者两次服药后治愈率差异均无统计学意义(第一次服药χ2=3.218、3.930、4.050,P>0.05;第二次服药χ2=1.745、1.902、0.329,P>0.05)。第1次服药后觉得吞药片困难、头晕、恶心、腹泻、呕
Objective To evaluate the efficacy of once and twice doses of albendazole in treating human soiltransmitted helminth infections.Methods From October 2015 to January 2016,school students of grades 2-6 in 5 primary schools were selected to participate baseline survey(in Blang Mountain Township,Menghai County,Xishuangbanna Prefecture,Yunnan Province.Fecal samples were collected for two consecutive days(one sample per day),each of which was used to prepare three slides and examined using Kato-Katz method by microscopy.Students with fecal egg-positive finding(Ascaris,hookworm,Trichuris single or mixed infections)are treated with albendazole(400 mg single dose).Three days after treatment,fecal samples were collected in consecutive 2 days.After 4 weeks,the same group of students received additional single dose of 400 mg albendazole and their fecal samples were collected 3 days after dosing and examined.A questionnaire survey was conducted at the same time of two medications to assess the adverse reactions.Students who were still egg-positive after twice dosing were treated with albendazole once more.The examinees of the five primary schools were summarized according to administrative villages to evaluste the therapeutic effect on Trichuris infection in different villages.The comparison of rates is conducted usingχ2 test.Results A total of 438 people from 5 schools were investigated,and the infection rate of soil-derived nematodes was 82.19%(360/438).The infection rate was 79.19%(175/221)in boys and 85.25%(185/217)in girls,with no significant difference(χ2=2.754,P>0.05).The infection rates of soil-transmitted helminth were 89.79%(299/333),90.57%(48/53),21.43%(9/42),4/10(χ2=133.781,P<0.05)among the Blang,Lahu,Hani and other ethnological populations,respectively.The infection rates were 73.97%(54/73),90.38%(94/104),73.56%(64/87),87.50%(28/32),84.51%(120/142),respectively(χ2=13.700,P<0.05).The infection rates of Ascaris,hookworm and Trichuris were 52.51%(230/438),35.39%(155/438)and 73.29%(321/438),respectively.The cure
作者
严信留
杜尊伟
杨亚明
汪丽波
吴方伟
李奔福
李鸿斌
陈然
字金荣
彭佳
蔡璇
保雪莹
唐小英
杨恒林
YAN Xinliu;DU Zunwei;YANG Yaming;WANG Libo;WU Fangwei;LI Benfu;LI Hongbin;CHEN Ran;ZI Jinrong;PENG Jia;CAI Xuan;BAO Xueying;TANG Xiaoying;YANG Henglin(Yunnan Institute of Parasitic Diseases,Pu’er 665000,China;Pu’er University,Pu’er 665000,Yunnan,China;Xishuangbanna Prefecture Center for Disease Control and Prevention,Xishuangbanna 666100,Yunnan,China;Menghai County Center for Disease Control and Prevention,Xishuangbanna 666200,Yunnan,China;Yanshan County Center for Disease Control and Prevention Pingyuan Branch Center,Wenshan 663101,Yunnan,China;Menghai County Blang Mountain Township Health Center,Xishuangbanna 666213,Yunnan,China)
出处
《中国寄生虫学与寄生虫病杂志》
CSCD
北大核心
2024年第2期204-210,共7页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
阿苯达唑
土源性线虫
疗效观察
不良反应
耐药性
Albendazole
Soil⁃transmitted helminth
Efficacy observation
Adverse reaction
Drug resistance
