摘要
目的探讨丁螺环酮对使用5-HT再摄取抑制剂（SSRI）维持治疗的缓解期女性抑郁症患苦性功能以及血清催乳素水平的影响。方法筛选120例以单一SSRI类抗抑郁剂治疗至少6月、具有固定配偶、汉密尔顿抑郁量表17项版本（HMAD．17）评分小于7分的康复期抑郁症女性患者，以亚利桑那性经验量表（ASEX）判定性功能障碍（sD）者40例，并予丁螺环酮15～30mg／d治疗4周，匹配社会人口学相符的正常对照组、非sD患者组（NSD）各40例，比较对照组、NsD组和丁螺环酮治疗前后sD组性功能和血浆催乳素水平，并分析sD可能的临床相关因素。结果120例康复期抑郁症患者sD总体发生率为33．3％，丁螺环酮治疗后性功能好转率为60％。SD组合并丁螺环酮治疗后ASEX总分、5个分因子分值低于合并用药前，差异有显著性（均P〈0．01）；SD组合并丁螺环酮治疗后血清催乳素水平[（20．38±11．91）ng/ml]高于正常对照组[（14．2±12．15）ng／ml]，差异有显著性（P=0．008），但与SD组合并用药前[（18．15±9．84）ng／m1]相比差异无统计学意义（P=1．0）。合并丁螺环酮治疗前患者ASEX总分与氟西汀（r=0．504，P=0．002）和帕罗西汀（r=0．377，P=0．013）剂量显著相关。在正常组、NSD组以及SD组合并丁螺环酮治疗前后均未发现ASEX总分与血催乳素水平显著相关。结论丁螺环酮辅助治疗可能有助于缓解SSRI类抗抑郁剂所致的性功能障碍。
Objective To determine the influence of buspirone on sexual function and plasma prolactin in rehabilitative female major depressive patients. Methods The female major depressive patients, who had a total HAMD-17 less than 7,were living with a sexual partner and receiving SSRI antidepressant monotherapy for at least six months were recruited. Sexual dysfunction （SD） was assessed using the Arizona Sexual Experience Scale （ASEX）. The patients with SD were treated with buspirone 15 - 30 mg by 4 weeks. Sexua function and blood samples were compared among the control, non-SD patients, and the SD patients before or after treating with buspi- rone. The clinical risk factor of SD was also investigated with correlation analysis. Results The general incidence of SD in rehabilitative female major depressive patients was 33.3%. The improvement rate of SD was 60% after the treatment of buspirone. The ASEX score and it 5 items were significantly decreased in the depressive patients after the treatment of buspirone （P 〈 0.01 ）. Prolactin in subjects treated with buspirone （ （20.38 ± 11.91 ） ng/ml） was significantly higher than control （ （ 14.2± 12. 15 ） ng/ml）, but not higher than the period prior to treatment with buspirone （ （18.15 ± 9.84）ng/ml）. The ASEX score was significantly correlated the dose of flnoxe- fine （ r = 0. 504, P = 0. 002） and paroxetine （ r = 0. 377, P = 0. 013 ）. There was no significantly correlation between ASEX score and prolactin in the control, non-SD patients, and the patients before or after treating with bnspirone. Conclusion Buspirone can release sexual dysfunction induced by SSRI antidepressant in the depressive patients.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2012年第6期484-487,共4页
Chinese Journal of Behavioral Medicine and Brain Science
关键词
5-HT再摄取抑制剂
性功能障碍
催乳素
Selective serotonin reuptake inhibitor
Sexual dysfunction
Prolactin
