摘要
目的研究抑郁症患者门诊用药情况及不同用药方式对患者生命质量(QOL)的影响。方法采用多中心合作研究,分析652名抑郁症患者的门诊用药情况,并对其中180名完成3次(治疗基期、治疗3mo和6mo)QOL随访的不同用药方式患者进行QOL(SF-36)评价。结果不伴焦虑的抑郁症(PD)患者门诊用药居前3位的分别是百忧解(40·61%)、赛乐特(27·65%)和氯硝安定(21·16%);而伴有焦虑的抑郁症(AD)患者门诊用药居前3位的分别是赛乐特(40·67%)、百忧解(21·45%)和氯硝安定(16·43%)。PD患者有61·77%采用联合用药,而AD患者43·73%采用联合用药,基期联合用药者QOL评分均明显低于单一用药者。无论是PD或AD患者,经抗抑郁药治疗后患者QOL均得到显著改善,尤其是联合用药者QOL的改善程度更高、更快。结论治疗6mo时患者QOL优于3mo时QOL,联合用药效果优于单一用药。
OBJECTIVE： To analyze the drugs and quality of life（QOL） in outpatients with depressive disorder receiving different antidcpressant in Shanghai. METHODS： A multi- center collaborative study was performed to analyze the prescriptions of 652 outpatients with depressive disorder and the QOL（SF 36）of 180 cases who had been treated with monotberapy or combined therapy at baseline, 3mo and 6mo were assessed at follow- ups. RESULTS： The top 3 drugs prescribed for outpaticnts without anxiety （pure depression, PD） were prozac （40.61%）, paroxetine （ 27.65 % ） and clonazepam （ 21.16% ）, respectively ; the top 3 drugs for outpatients complicated with anxiety symptoms （AD） were seroxat （40.67%）, prozac （ 21.45% ） and clonazepam （16.43%）, respectively. 61.77% of PD patients were treated with combinatied therapy, hut cmly 43.73% in AD patients with combination therapy. QOL scores in patients receiving combination therapy were significantly lower at baseline than in patients receiving single therapy. After treatment,the QOL scores in either PD or AD patients improved signifreantly , much as in case of combination therapy. CONCLUSION.. QOL of patients were higher at 6mo than at 3mo; conbinotion therapy is superior to monotherapy.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第22期1717-1720,共4页
China Pharmacy
关键词
抑郁症
门诊用药
生命质量
随访
Depression disorder
Outpatient medication
Quality of life
Follow- up
