摘要
目的回顾性分析前列腺素E1不良反应的发生情况,为临床合理用药提供参考。方法收集湖南省各医疗机构2005年4月～2011年5月上报有关前列腺素E1的163例不良反应报告,利用SPSS 18.0软件分别对患者性别、年龄、用药情况、ADR临床表现等进行分类汇总和统计分析。结果 ADR在用药各年龄人群均可发生,60～69岁年龄段发生ADR的比例最高(29.45%);以局部反应、胃肠道不良反应和过敏反应为主,全部为轻、中度;主要于用药当日发生,大多需要停药和对症处理。结论在前列腺素E1的临床应用中应加强不良反应监测,发现不良反应应及时停药并对症处理,保障用药安全。
Objective To retrospectively analyze the adverse effect of prostaglandin E1 and to provide reference for clinical rational administration. Methods A total of 163 prostaglandin E1 injection-induced ADR cases reported in hospitals in Hunan from April 2005 to May 2011 were collected and analyzed statistically with SPSS 18. 0 in respect of age, gender, medication and clinical manifestation, etc. Results ADR cases occurred nearly in all age groups and 29.45% appeared in the 60--69 age group. Main clinical manifestations were local reaction, gastrointestinal side effects and allergic reaction, most of which were mild and medium ADR. Conclusion We should strengthen the monitoring of ADR in the clinical application of prostaglandin El. Medical staff should discontinue treatment to improve the security of drug use when ADR occurs.
出处
《中南药学》
CAS
2012年第5期395-398,共4页
Central South Pharmacy
关键词
前列腺素E1
不良反应
合理用药
prostaglandin El
adverse drug reaction
rational administration
