期刊文献+

前列地尔脂微球载体制剂治疗糖尿病肾病的临床观察 被引量:17

Study of efficacy on lipo PGE1 in treatment of diabetic nephropathy
下载PDF
导出
摘要 目的:观察前列地尔脂微球载体制剂(Lipo PGE1)对糖尿病肾病的治疗效果。方法:选择60例确诊为糖尿病的患者,均为临床蛋白尿期,随机分为2组,治疗组在与对照组相同基础治疗上,Lipo PGE1 10"g每日静脉推注1次,疗程4周。观察治疗前后血肌酐(Scr),尿白蛋白排泄(UAER)等指标。结果:治疗组在使用Lipo PGE1后血肌酐(Scr),尿白蛋白排泄(UAER)明显下降(P<0.05)。结论:Lipo PGE1对糖尿病肾病有较好的治疗效果。 Objective:To observe the effects of Lipo PGE1 in Treatment of Diabetic nephropathy (DN). Methods:60 patients with clinical albuminuria were divided randomly into the treatment group and control group,receiving regular treatment. In addition,the cases of treatment group received treatment of PGE1 lOng daily for two weeks. The index of Scr and UAER were observed before and after treatment. Results:The Scr and UAER in treatment group were more decreased than those in control group. Conclusion:Lipo PGE1 is effective in treating Diabetic nephropathy.
作者 南映瑜
出处 《重庆医科大学学报》 CAS CSCD 2008年第1期127-128,共2页 Journal of Chongqing Medical University
关键词 前列地尔(凯时) 糖尿病肾病(DN) Liop PGE1 Diabetic nephropathy
  • 相关文献

参考文献5

二级参考文献13

  • 1邹立军,李媛明,韩会芹,庄庆媛,刘海燕,宋亚贵.前列腺素E_1治疗糖尿病64例临床观察[J].吉林医学,1994,15(1):29-30. 被引量:13
  • 2杨钢,内分泌生理与病理生理学,1996年,426页 被引量:1
  • 3杨乃龙,中华器官移植杂志,1993年,14卷,159页 被引量:1
  • 4Cawello W,Leonhardt A,Schweer H,etal.Dose proportional pharmacokinetics of alpro-stadil (prostaglandin E1)in healthyvolunteers following intravenous infusion 〔J〕.Br J Clin Pharmacol,1995,40:273~276. 被引量:1
  • 5Anggard E.The biological activities of three metabolites of prostaglandin E1 〔J〕.ActaPhysiol Scand,1996,66:509~510. 被引量:1
  • 6Yasuda H,Maeda K,Sonobe M,et al.Metabolic effect of PGE1 analogue O1206.αCD onnerve Na+-K+-ATPase activity of rats with streptozotocin-induced diabetes is mediatedvia cAMP: possible role of cAMP in diabetic neuropathy 〔J〕.Prostaglandins,1994,47:367~378. 被引量:1
  • 7Okada S,Ichiki K,Tanokuchi S,et al.Effect of prostaglandin E1 on therenin-aldosterone system in patients with diabetic nephropathy 〔J〕.J Int MedRes,1993,21:126~132. 被引量:1
  • 8Young MJ, Veves A,Smith JV, et al.Restoring lower limb blood flow improvesconduction velocity in diabetic patients 〔J〕.Diabetologia,1995,38:1051~1054. 被引量:1
  • 9Partanen J,Niskanen L,Lehtinen J,et al.Natural history of peripheral neuropathy inpatients with non-insulin-dependent diabetes mellitus 〔J〕. N Engl J Med,1995,333:89~94. 被引量:1
  • 10Yasuda H,Sonobe M,Hatanaka I,et al.A new prostaglandin E1 analogue (TFC-612)prevents a decrease in motor conduction velocity in streptozocin-diabetic rats 〔J〕.BiochemBiophys Res Commun,1998,150:225~230. 被引量:1

共引文献815

同被引文献126

引证文献17

二级引证文献98

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部