摘要
开展了邻苯二胺与4-甲基苯甲醛、4-硝基苯甲醛及4-二甲氨基苯甲醛反应生成苯并咪唑衍生物的微波辅助合成研究。用高效液相色谱法(HPLC)测定其产率。结果表明:相同反应时间,在微波辅助条件下,生成苯并咪唑衍生物的反应产率均较常规加热条件下增大,并且芳醛对位上取代基吸电子能力越强,反应产率越高。
Microwave assisted organic synthesis of benzimidazole derivatives through the reaction of o-phenylenediamine with 4-ni- trobenzylaldehyde,4-methylbenzylaldehyde and 4-dimethylaminobenzylaldehyde was investigated. High performance liquid chroma- tography（HPLC） was applied to the determination of the yield. The results showed that the yield was improved significantly when the reaction was carried out under microwave irradiation. When the electron withdrawing ability of substituent at p-benzaldehyde became stronger, the yield of the reaction was improved too.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2012年第6期932-935,共4页
Chemical Research and Application
基金
科技部国际合作项目(2006DFA43520)资助项目
中央高校基本科研业务费项目(CDJXS10220017)资助项目
关键词
微波辅助合成
电子效应
苯并咪唑
衍生物
microwave-assisted synthesis
electric effect
benzimidazoie
derivatives
