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老年人小肠脂肪酸结合蛋白基因54位密码子多态性与血脂水平的关系 被引量:1

Relationship between Ala 54 Thr polymorphism of intestinal fatty acid-binding protein 2 gene and plasma lipids in old population
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摘要 目的调查老年人小肠脂肪酸结合蛋白(I-FABP)基因外显子2中54位点密码子A/T单核苷酸多态性和不同基因型人群的血脂水平,探讨LFABP基因多态性与老年人血脂水平的关系。方法采用聚合酶链反应(PCR)、DNA限制性内切酶酶切等技术对72例汉族老年人54A/TI—FABP基因型进行分析;用全自动生化仪检测人选人群的血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL—C)和低密度脂蛋白胆固醇(LDL—C)水平。结果基因型分组Thr54(-)组、Thr54(+)组各36例,Thr54(-)组与Thr54(+)组比较,TC为(4.50±0.73)mmol/L与(5.48±0.49)mmol/L、TG为(1.08±0.48)mmol/L与(2.02±0.53)mmo[/L、LDL_C为(3.10±0.44)mmo|/L与(3.50±0.66)mmol/L和HDL—C为(1.14±0.25)mmol/L与(0.96±0.23)mmol/L,差异有统计学意义(£值分别为一6.67、-7.84、-3.03、3.05,均P〈0.05)。结论H7AB外显子2中54位点密码子A/TSNP与老年人群的血脂水平相关。 Objective To investigate relationship between Ala 54 Thr polymorphism in the intestinal fatty acid-binding protein (I-FABP) and plasma lipids in old people. Methods We collected fasting blood samples of selected groups, then we extracted DNA from whole blood, and detected lipids from serum. The 54A/T I-FABP genotypes were analyzed in 72 Han Chinese elderly by polymerase chain reaction (PCR) and DNA restriction enzyming. Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were detected. Genotype subgroups were Thr54 ( - ) and Thr54 ( + ) groups (36 cases for each) . Results Compared with Thr54 (-) genotype group, Thr54 (+) genotype group had higher levels of plasma TC((4.50~0.73) mmol/L vs. (5.48±0.49)mmol/L;, TG[(1.08±0.48) mmol/L vs. (2.02±0.53) mmol/L], LDL-C [(3.10±0. 44) mmol/L vs. (3.50=[=0.66)mmol/L3, and had lower level of HDL-C ((1.14+0. 25) mmol/L vs. (0.96±0.23)mmol/L)(t=-6.67,-7.84,-3.03, 3.05, all P〈0.05). Conclusions In the old populations, the frequency of 54Ala/Thr polymorphism in I-FABP gene is correlated with high level of lipoprotein.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2012年第6期451-453,共3页 Chinese Journal of Geriatrics
基金 内蒙古自治区科技计划项目(20080502)
关键词 脂肪酸结合蛋白质类 多态性 单核苷酸 脂代谢障碍 Fatty acid-binding proteins Polymorphism, single nueleotide Lipid metabolism disorders
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