结核性脑膜炎患者脑脊液中微管相关蛋白1轻链-3的表达被引量：1

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摘要结核性恼膜炎可能导致严重的后果，早期诊断是影响患者预后的关键因素，但目前尚缺少行之有效的方法。MTB感染后，免疫细胞对病原体的自噬性吞噬是宿主对MTB感染天然免疫的重要机制，也是获得性免疫抗原呈递过程的重要环节，且具有潜在的治疗意义。

作者程言博李新华葛巍董艳陈敏周延龙董瑞国耿德勤

机构地区徐州医学院附属医院神经内科新疆维吾尔自治区伊犁哈萨克自治州奎屯医院神经内科

出处《中华结核和呼吸杂志》 CAS CSCD 北大核心 2012年第6期455-456,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases

关键词结核性脑膜炎微管相关蛋白患者脑脊液 MTB感染轻链获得性免疫早期诊断

分类号 R529.3 [医药卫生—内科学]

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参考文献9

1Galimi R. Fxtrapuhnonary tuberculosis: tuberculous meningitis new developments. Eur Rev Med Pharmacol Sci, 2011, 15: 365- 386. 被引量：1
2Garg RK. Tuberculous meningitis. Acta Neurol Stand, 2010, 122 : 75-90. 被引量：1
3Rock RB, Olin M, Baker CA, el al. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Mictx~biol Rev, 2008, 21: 243-261. 被引量：1
4Ni Cheallaigh C, Keane J, l,avelle EC, et al. Aulophagy in the immune response to tuberc uh s s: clinical perspectives. Clin Exp lmmunol, 2011, 164: 291-300. 被引量：1
5Thwaites GE, Chau TF, Stepniewska K, et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. l,ancet. 2002, 360 : 1287-1292. 被引量：1
6Jeffery K J, Read SJ, Peto TE, et al. Diagnosis of viral infections of the eentral nervous system clinical inteli)retation of PCR resuhs, l,aneet, 1997, 349: 313-317. 被引量：1
7Deretic V, Singh S, Master S, et al. Myeobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defenee mechanism. Cell Microbiol, 2006, 8: 719-727. 被引量：1
8顾晓玲,张红梅,王洪海.结核分枝杆菌持续感染期分子机制的研究进展[J].中华结核和呼吸杂志,2005,28(1):47-49. 被引量：1
9Gulierrez MG, Master SS, Singh SB, et al. Autophagy is a defense mechanism inhibiting BCG and Myeobacterium tuberculosis survival in infecled macrophages. Cell, 2004, 119: 753-766. 被引量：1

二级参考文献21

1Weber I, Fritz C, Ruttkowski S, et al. Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice. Mol Microbiol,2000, 35 : 1017-1025. 被引量：1
2Chemens DL, Lee BY, Howitz MA. Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and LegioneUa pneumophila is associated with altered phagosomal fate. Infect Immun, 2000, 68: 2671-2684. 被引量：1
3Pieters J, Gatfield J. Hijacking the host: survival of pathogenic mycobacteria inside macrophages. Trend Microl,2002,10 : 142-146. 被引量：1
4Vergne I, Chua J, Deretic V, et al. Tuberculosis Toxin Blocking Phagosome Maturation Inhibits a Novel Ca^2+/Camodulin-PI3K Hvps34 Cascade. J Exp Med, 2003, 198: 653-659. 被引量：1
5McCune RM, Tompsrtt R, McDermott W. The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. Ⅱ. The conversion of tuberculous infection to the latent state by the administration of pyrazinamide and a companion drug. J Exp Med, 1957, 104: 763-802. 被引量：1
6Wayne LG, Sohaskey CD. Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol, 2001, 55: 139-163. 被引量：1
7Scanga CA, Mohan VP, Joseph H, et al. Reactivation of latent tuberculosis: variations on the Comell murine model. Infect Immun,1999, 67: 4531-4538. 被引量：1
8Betts JC, Lukey PT, Robb LC, et al. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol, 2002, 43: 717-731. 被引量：1
9Cole ST, Brcsch R, Parkhill J, et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.Nature, 1998, 393: 537-544. 被引量：1
10McKinney JD, Honer zu Bentrup K, Munoz-Elias E J, et al. Persistence of Mycobactefium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isoxitrate lyase. Nature, 2000,406: 735-738. 被引量：1