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TNFα-850C/T基因多态性与儿童哮喘相关性的初步探讨 被引量:1

Study on TNFα-850C/T polymorphisnis in patients with Asthma
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摘要 目的探讨肿瘤坏死因子TNFα-850C/T基因多态性与儿童哮喘的关系。方法运用多聚酶链反应技术检测100例儿童哮喘及100例正常人肿瘤坏死因子TNFα-850C/T基因多态性。结果儿童哮喘组肿瘤坏死因子TNFα-850C/C、T/C、T/T表型频率分别为:0.7100、0.2700、0.02,对照组分别为0.7900、0.1900、0.020;儿童哮喘组TNFα-850T、TNFα-863C基因频率分别为:0.8450、0.1550,对照组分别为:0.8850、0.1150;TNFα-850C/T各种基因型频率在儿童哮喘组与正常对照组之间差异无统计学意义(P>0.05)。结论肿瘤坏死因子TNFα-850C/T基因多态性与儿童哮喘无明显相关。 Objective To investigate the relationship between tumor necrosis factor (TNF) -- 850C/T polymorphism and Asthma. Methods The polymorphism of TNFα-850C/T gene was screened by PCR--RELP. Results the gene frequency of TNFa--850C/T in verities group as followed; TNFα- 850 C/C, T/C, T/T genotype frequency: 0. 7100, 0. 2700, 0. 02TNFα- 850 C, TNFα-850 T Gene frequency: 0. 8450, 0. 1550. TNFα-850 C/C, T/C, T/T genotype frequency in control group was as followed: 0.7900, 0. 1900, 0. 020,TNFα-850 C, TNFα-850 T Gene frequency: 0. 8850, 0. 1150. There were no significant differences in the frequencies of TNFα-850C/T gene between Asthma patients and control group (P) 0. 05). Conclusions No evident association is found between TNFα-850C/T polymorphism and Asthma.
出处 《齐齐哈尔医学院学报》 2012年第8期986-988,共3页 Journal of Qiqihar Medical University
关键词 儿童哮喘 肿瘤坏死因子α-850C/T 多态性 TNFα-850C/T gene Asthma Polymorphism
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