摘要
目的探讨转化生长因子(TGF)β1-509C/T基因多态性与变应性鼻炎的关系。方法运用多聚酶链反应技术检测63例变应性鼻炎及110例正常人转化生长因子TGFβ1-509C/T基因多态性。结果变应性鼻炎组转化生长因子TGFβ1-509C/C、C/T、T/T表型频率分别为0.0953、0.3809、0.5238;对照组分别为0.1545、0.40、0.4455;变应性鼻炎组TGFβ1-509C、TGFβ1-509T基因频率分别为0.2857、0.7143,对照组分别为0.3545、0.6455,TGFβ1-509C/T各种基因型频率在患者组与正常对照组之间的差异无统计学意义(P>0.05)。结论TGFβ1-509C/T基因多态性与变应性鼻炎无明显相关。
Objective To investigate the relationship of TGFβ1-509C/T polymorphism and allergic rhinitis. Methods The polymorphism of TGFβ1-509C/T gene was screened by PCR-RELP in 63 patients with allergic rhinitis（AR group） and 110 normal people. Results The gene frequency of TGFβ1-509C/T in AR group was as follow： TGFβ1-509 C/C, C/T and T/T genotype frequency was 0.0953, 0.3809 and 0.5238, respectively, the gene frequency in control group was O. 1545, 0.40 and 0.4455; TGFβ1-509C, TGFβ1-509T gene frequency was 0.2857 and 0.7143 respectively, in control group, TGFβ1-509C, TGFβ1-509T genefrequency was 0.3545, and 0.6455 respectively. There were no significant differences in the frequencies of TGFβ1-509C/T gene between the patient and control group （P〉0.05）. Conclusion No evident association was found between TGFβ1-509C/T polymorpbism and allergic rhinitis.
出处
《解剖学研究》
CAS
2009年第2期85-87,共3页
Anatomy Research
关键词
变应性鼻炎
转化生长因子
多态性
Allergic rhinitis
Transforming growth factor
Polymorphism
