摘要
目的 探讨重叠综合征（OS）患者血清瘦素（leptin）、胰岛素样生长因子-1（IGF-1）与骨密度（BMD）、骨矿含量（BMC）的关系.方法 应用双能X线吸收骨密度仪对22例OS、24例阻塞性睡眠呼吸暂停低通气综合征（OSAHS）、26例慢性阻塞性肺疾病（COPD）患者进行腰椎、股骨近端BMD、BMC测定,放射免疫法测定血清leptin、IGF-1,并与对照组比较.结果 OS、OSAHS、COPD组患者BMD、BMC、IGF-1与对照组比较明显降低,差异均有统计学意义（P＜0.05或0.01）;OS、OSAHS组患者leptin与对照组比较明显升高,差异均有统计学意义（P＜0.05或0.01）,而COPD组患者与对照组比较明显降低（P＜0.05或0.01）.leptin与BMD及BMC在OS组和OSAHS组呈负相关（均P＜0.05）,在COPD组则无相关性;3组IGF-1与BMD均无相关性而与BMC呈正相关（均P＜0.05）.结论 OS、OSAHS组患者leptin与BMD及BMC均有相关性,OS、OSAHS、COPD组患者IGF-1与BMC有相关性.
Objective To investigate the associations of serum leptin and insulin-like growth factor-1 （IGF-1） levels with bone mineral density （BMD） and bone mineral content （BMC） in patients with overlap syndrome （OS）. Methods BMD and BMC in 22 patients with OS, 24 patients with obstructive sleep apnea/hypopnea syndrome （OSAHS） and 26 patients with chronic ob- structive pulmonary disease （COPD） were measured by dual-energy X-ray absorptiometry. Serum leptin and IGF-1 levels were measured by radioimmunoassay. The results were compared with those of 20 healthy subjects（control group）. Results BMD, BMC and serum IGF-1 levels in OS, OSAHS and COPD groups were significantly lower than those in control group （P〈0.05）. Serum leptin levels in OS and OSAHS groups were higher, but in COPD group were lower than those in controls （all P〈0.05）. Serum leptin levels in OS and OSAHS groups were negatively correlated with BMD and BMC, but those in COPD group were not correlated with BMD and BMC. Serum IGF-1 levels in OS, OSAHS and COPD groups were positively correlated with BMC and not correlated with BMD. Conclusion In patients with OS and OSAHS, serum leptin levels are correlated with BMD and BMC. In patients with OS, OSAHS and COPD, serum IGF-1 levels were correlated with BMC.
出处
《浙江医学》
CAS
2012年第8期593-595,共3页
Zhejiang Medical Journal
