摘要
目的探讨β-受体阻滞剂联合胺碘酮对心衰患者的临床疗效及对心功能的影响。方法选取2016年10月至2017年10月期间于本院就诊的心衰患者80例为研究对象。随机分为对照组和观察组,各40例。所有患者入院后均给予利尿剂、血管扩张剂等常规抗心衰治疗,对照组在常规治疗基础上给予盐酸胺碘酮片治疗,观察组在对照组基础上给予阿替洛尔片进行治疗。比较两组患者治疗前后LVEF、SV、LVEDD以及LVESD变化情况及临床疗效。结果两组患者治疗前LVEF、SV、LVEDD、LVESD比较差异无统计学意义,治疗后LVEF、SV均显著升高,LVEDD、LVESD均显著降低(P<0.05);观察组治疗后LVEF、SV均显著高于对照组,LVEDD、LVESD均显著低于对照组(P<0.05)。观察组显效29例(72.50%)、总有效39例(97.50%),对照组显效17例(42.50%)、总有效32例(80.00%),观察组显效率及总有效率均明显高于对照组(P<0.05)。结论β-受体阻滞剂联合胺碘酮能够显著改善心衰患者的心功能,临床疗效显著,且用药安全,值得推广应用。
Objective To investigate the clinical effect of beta blocker combined with amiodarone on heart failure and its effect on cardiac function.Methods During October2016to October201780patients with heart failure were selected as the subjects in our hospital.The control group and the observation group were randomly divided into40cases.All patients were given diuretics,vasodilator and other conventional anti heart failure therapy,the control group on the basis of routine treatment for Amiodarone Hydrochloride Tablets treatment,observation group in the control group were given treatment of Atenolol Tablets.The changes of LVEF,SV,LVEDD and LVESD before and after treatment in the two groups were compared and the clinical effects were compared.Results Two groups of patients before treatment,LVEF,SV,LVEDD and LVESD had no significant difference,LVEF after treatment,SV was significantly increased,LVEDD and LVESD were significantly decreased(P<0.05);the observation group after treatment LVEF,SV were significantly higher than control group,LVEDD and LVESD were significantly lower than the control group(P<0.05).In the observation group,29cases(72.50%)were markedly effective,39cases(97.50%)were total effective,17cases(42.50%)were markedly effective in the control group,32cases(80.00%)were total effective,and the effective rate and the total effective rate in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Beta blocker combined with amiodarone can significantly improve cardiac function in patients with heart failure.The clinical effect is significant,and it is safe to use.It is worthy of popularization and application.
作者
王辉
Wang Hui(Department of Cardiology, Yuncheng County People' s Hospital, Yuncheng, Shandong, 274700, China)
出处
《当代医学》
2018年第35期45-47,共3页
Contemporary Medicine
关键词
阿替洛尔
胺碘酮
心力衰竭
心功能
临床疗效
Atenolol
Amiodarone
Heart failure
Cardiac function
Clinical curative effect
